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Gene Review

TMEM132D  -  transmembrane protein 132D

Homo sapiens

Synonyms: HBE120, KIAA1944, MOLT, Mature OL transmembrane protein, Mature oligodendrocytes transmembrane protein, ...
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Disease relevance of TMEM132D


Psychiatry related information on TMEM132D

  • In insects, the neuropeptide eclosion hormone (EH) acts on the CNS to evoke the stereotyped behaviors that cause ecdysis, the shedding of the cuticle at the end of each molt [6].
  • They suggest that 20-HE orchestrates intrinsic, cellular, and nuclear events that produce the molt-cycle transformations in agonistic behavior and aggressive state of lobsters [7].
  • Plasma LH levels followed the same trend as testosterone, falling after copulation and falling further prior to molt [8].
  • It is well known in this species that day 4 following feeding is the end of a critical period for the insect in determining whether it will proceed to the next molt [9].
  • Endogenous gonadal, LH and molt rhythms in tropical stonechats: effect of pair bond on period, amplitude, and pattern of circannual cycles [10].

High impact information on TMEM132D

  • A cDNA clone YT35 , synthesized from poly(A)+ RNA of the human T cell tumor Molt 3, exhibits homology to the variable (V), joining (J), and constant (C) regions of immunoglobulin genes [11].
  • The Caenorhabditis elegans heterochronic genes control the relative timing and sequence of many events during postembryonic development, including the terminal differentiation of the lateral hypodermis, which occurs during the final (fourth) molt [12].
  • At the end of each molt, insects shed the old cuticle by performing preecdysis and ecdysis behaviors [13].
  • We now report that certain human leukemia cell lines including HL60, HEL, and Molt 4 express mRNA for both alpha and alpha 3 isoforms of Na+,K+-ATPase; mRNA was not detected in several other cell lines, including K562 and U937; no cell lines expressed alpha+ mRNA [14].
  • Nonimmune rosette formation of human peripheral blood lymphocytes and cultered MOLT 3 and MOLT 4 cells with sheep red blood cells was studied by transmission electron microscopy [15].

Chemical compound and disease context of TMEM132D


Biological context of TMEM132D

  • We find that, unlike metamorphosing insects, in which br expression is restricted to the larval-pupal transition, Of'br mRNA is expressed during embryonic development and is maintained at each nymphal molt but then disappears at the molt to the adult [21].
  • PFGE analysis of the T cell line Molt 4 suggests a greater than 600-kb deletion involving the TCR-alpha gene [22].
  • Suppression of a thioesterase gene expression and the disappearance of short chain fatty acids in the preen gland of the mallard duck during eclipse, the period following postnuptial molt [23].
  • Both L161 and 0249F also induced a comparable increase in the intracellular Ca2+ concentration on MOLT 4 and JURKAT, two other T cell lines of similar phenotype [24].
  • Treatment of the leukemia lines Ha and Molt 3, with the methylation inhibitor, 5-aza-2'-deoxycytidine (5-aza-CdR) resulted in increased Syk mRNA expression [25].

Anatomical context of TMEM132D


Associations of TMEM132D with chemical compounds

  • Cryptocyanin resembles insect hexamerins in the lack of copper, molt cycle patterns of biosynthesis, and potential contributions to the new exoskeleton [30].
  • In contrast, induction of a precocious adult molt by application of precocene II to third-stage nymphs caused a loss of br mRNA at the precocious adult molt [21].
  • When MOLT 4 cells were exposed to 1 microM methotrexate, the monoglutamate attained a steady state after 30 min, and polyglutamyl derivatives having from one to 4 additional glutamyl residues were observed over 4 hr [2].
  • The influx of tubercidin into MOLT 4 cells was found to occur primarily by means of the NBMPR-sensitive nucleoside transport system [31].
  • These studies show that in MOLT 4 cells (a) both methotrexate and 7-hydroxymethotrexate are rapidly converted to polyglutamyl derivatives, and (b) 7-hydroxymethotrexate interferes with net methotrexate accumulation and metabolism when present simultaneously in the extracellular medium [2].

Analytical, diagnostic and therapeutic context of TMEM132D


  1. Ultrastructural demonstration of terminal deoxynucleotidyl transferase (TdT). Steinmann, G., Mertelsmann, R., deHarven, E., Moore, M.A. Blood (1981) [Pubmed]
  2. In vitro formation of polyglutamyl derivatives of methotrexate and 7-hydroxymethotrexate in human lymphoblastic leukemia cells. Fabre, G., Matherly, L.H., Favre, R., Catalin, J., Cano, J.P. Cancer Res. (1983) [Pubmed]
  3. Identification of 5'-flanking regions affecting the expression of the human decay accelerating factor gene and their role in tissue-specific expression. Thomas, D.J., Lublin, D.M. J. Immunol. (1993) [Pubmed]
  4. Cellular metabolism of 2',3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro. Starnes, M.C., Cheng, Y.C. J. Biol. Chem. (1987) [Pubmed]
  5. Successful production of intrathyroidal human T cell hybridomas: evidence for intact helper T cell function in Graves' disease. Martin, A., Schwartz, A.E., Friedman, E.W., Davies, T.F. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  6. Neuropeptide induction of cyclic GMP increases in the insect CNS: resolution at the level of single identifiable neurons. Ewer, J., De Vente, J., Truman, J.W. J. Neurosci. (1994) [Pubmed]
  7. 20-hydroxyecdysone causes increased aggressiveness in female American lobsters, Homarus americanus. Bolingbroke, M., Kass-Simon, G. Hormones and behavior. (2001) [Pubmed]
  8. The endocrine control of reproduction and molt in male and female emperor (Aptenodytes forsteri) and adelie (Pygoscelis adeliae) penguins. I. Annual changes in plasma levels of gonadal steroids and LH. Groscolas, R., Jallageas, M., Goldsmith, A., Assenmacher, I. Gen. Comp. Endocrinol. (1986) [Pubmed]
  9. Changes in the rate of CO2 release following feeding in the insect Rhodnius prolixus. Bradley, T.J., Brethorst, L., Robinson, S., Hetz, S. Physiol. Biochem. Zool. (2003) [Pubmed]
  10. Endogenous gonadal, LH and molt rhythms in tropical stonechats: effect of pair bond on period, amplitude, and pattern of circannual cycles. Gwinner, E., König, S., Zeman, M. J. Comp. Physiol. A (1995) [Pubmed]
  11. The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Siu, G., Clark, S.P., Yoshikai, Y., Malissen, M., Yanagi, Y., Strauss, E., Mak, T.W., Hood, L. Cell (1984) [Pubmed]
  12. Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins. Jeon, M., Gardner, H.F., Miller, E.A., Deshler, J., Rougvie, A.E. Science (1999) [Pubmed]
  13. Steroid induction of a peptide hormone gene leads to orchestration of a defined behavioral sequence. Zitnan, D., Ross, L.S., Zitnanova, I., Hermesman, J.L., Gill, S.S., Adams, M.E. Neuron (1999) [Pubmed]
  14. Expression of multiple Na+,K+-adenosine triphosphatase isoform genes in human hematopoietic cells. Behavior of the novel A3 isoform during induced maturation of HL60 cells. Gilmore-Hebert, M., Schneider, J.W., Greene, A.L., Berliner, N., Stolle, C.A., Lomax, K., Mercer, R.W., Benz, E.J. J. Clin. Invest. (1989) [Pubmed]
  15. Electron microscope study on human lymphocyte-sheep erythrocyte rosettes. Kataoka, K., Minowada, J., Pressman, D. J. Natl. Cancer Inst. (1975) [Pubmed]
  16. Effects of 8-aminoguanosine on the toxicity of guanosine and deoxyguanosine for malignant and normal lymphoid cells. van der Kraan, P.M., van Zandvoort, P.M., De Abreu, R.A., Bakkeren, J.A. J. Leukoc. Biol. (1988) [Pubmed]
  17. The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species. Balzarini, J., Pauwels, R., Baba, M., Herdewijn, P., de Clercq, E., Broder, S., Johns, D.G. Biochem. Pharmacol. (1988) [Pubmed]
  18. Daily melatonin injections affect the expression of circadian rhythmicity in Djungarian hamsters kept under a long-day photoperiod. Puchalski, W., Lynch, G.R. Neuroendocrinology (1988) [Pubmed]
  19. Ecdysteroid-responsive genes, RXR and E75, in the tropical land crab, Gecarcinus lateralis: differential tissue expression of multiple RXR isoforms generated at three alternative splicing sites in the hinge and ligand-binding domains. Kim, H.W., Lee, S.G., Mykles, D.L. Mol. Cell. Endocrinol. (2005) [Pubmed]
  20. Variations in plasma corticosterone, estrone, estradiol-17 beta, and progesterone concentrations with forced renesting, molt, and body weight of captive female American kestrels. Rehder, N.B., Bird, D.M., Laguë, P.C. Gen. Comp. Endocrinol. (1986) [Pubmed]
  21. The pupal specifier broad directs progressive morphogenesis in a direct-developing insect. Erezyilmaz, D.F., Riddiford, L.M., Truman, J.W. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  22. Sizing of the human T cell receptor alpha locus and detection of a large deletion in the Molt-4 cell line. Roth, M.S., Collins, F.S., Ginsburg, D. Blood (1988) [Pubmed]
  23. Suppression of a thioesterase gene expression and the disappearance of short chain fatty acids in the preen gland of the mallard duck during eclipse, the period following postnuptial molt. Kolattukudy, P.E., Rogers, L., Flurkey, W. J. Biol. Chem. (1985) [Pubmed]
  24. CD1 stimulation of human T cell lines induces a rapid increase in the intracellular free Ca2+ concentration and the production of IL-2. Theodorou, I.D., Boumsell, L., Calvo, C.F., Gouy, H., Beral, H.M., Debre, P. J. Immunol. (1990) [Pubmed]
  25. Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia. Goodman, P.A., Burkhardt, N., Juran, B., Tibbles, H.E., Uckun, F.M. Oncogene (2003) [Pubmed]
  26. Molecular cloning of a novel transmembrane protein MOLT expressed by mature oligodendrocytes. Nomoto, H., Yonezawa, T., Itoh, K., Ono, K., Yamamoto, K., Oohashi, T., Shiraga, F., Ohtsuki, H., Ninomiya, Y. J. Biochem. (2003) [Pubmed]
  27. Proteins IEF (isoelectric focusing) 31 and IEF 46 are keratin-type components of the intermediate-sized filaments: keratins of various human cultured epithelial cells. Bravo, R., Fey, S.J., Larsen, P.M., Coppard, N., Celis, J.E. J. Cell Biol. (1983) [Pubmed]
  28. The anatomy of a compartment border. The intersegmental boundary in Oncopeltus. Lawerence, P.A., Green, S.M. J. Cell Biol. (1975) [Pubmed]
  29. Stimulation of HLA-A,B,C by IFN-alpha. The derivation of Molt 4 variants and the differential expression of HLA-A,B,C subsets. Burrone, O.R., Kefford, R.F., Gilmore, D., Milstein, C. EMBO J. (1985) [Pubmed]
  30. Cryptocyanin, a crustacean molting protein: evolutionary link with arthropod hemocyanins and insect hexamerins. Terwilliger, N.B., Dangott, L., Ryan, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  31. Transport and metabolism of 9-beta-D-arabinofuranosylguanine in a human T-lymphoblastoid cell line: nitrobenzylthioinosine-sensitive and -insensitive influx. Prus, K.L., Averett, D.R., Zimmerman, T.P. Cancer Res. (1990) [Pubmed]
  32. Control of HLA-A,B,C synthesis and expression in interferon-treated cells. Burrone, O.R., Milstein, C. EMBO J. (1982) [Pubmed]
  33. G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2. de Vet, E.C., Aguado, B., Campbell, R.D. J. Biol. Chem. (2001) [Pubmed]
  34. Natural infection of a household pet red-capped mangabey (Cercocebus torquatus torquatus) with a new simian immunodeficiency virus. Georges-Courbot, M.C., Lu, C.Y., Makuwa, M., Telfer, P., Onanga, R., Dubreuil, G., Chen, Z., Smith, S.M., Georges, A., Gao, F., Hahn, B.H., Marx, P.A. J. Virol. (1998) [Pubmed]
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