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Gene Review

Klf5  -  Kruppel-like factor 5

Mus musculus

Synonyms: 4930520J07Rik, BTE-binding protein 2, Basic transcription element-binding protein 2, Bteb2, CKLF, ...
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High impact information on Klf5

  • Among the putative Wnt-1 target genes, we have identified a mouse homolog of the gene encoding human transcription factor basic transcription element binding protein 2 (mBTEB2) [1].
  • Finally, results of co-transfection studies showed that overexpression of IKLF/KLF5 reversed GKLF-dependent repression thus supporting a model of reciprocal activation-repression of SMC gene expression by different members of the KLF gene family [2].
  • Krüppel-like factor5 (Klf5) is a zinc-finger transcription factor normally expressed in the skin [3].
  • Here, we show that overexpression of Klf5 in the basal layer of the epidermis during embryogenesis affects epidermal development and disrupts epithelial-mesenchymal interactions necessary for skin adnexae formation as well as craniofacial morphogenesis [3].
  • Extending our previous observation that KLF5 activates cyclin D1 transcription to promote G1/S transition, our current results further support a crucial function for KLF5 in mediating cellular transformation caused by oncogenic H-Ras [4].

Biological context of Klf5


Anatomical context of Klf5


Associations of Klf5 with chemical compounds

  • Arsenite induced the expression of HO1, HIF1alpha, KLF5, PPARgamma and C/EBPalpha [8].

Regulatory relationships of Klf5

  • ILK expression restored migratory capacity in keratinocytes with suppression of Klf5, whereas ILK small interfering RNA blocked the increased migration resulting from Klf5 overexpression [9].

Other interactions of Klf5

  • Here, we examined the developmental expression of the mouse Klf5 gene and compared it to the established pattern of the Klf4 gene [6].
  • Conversely, over-expression of KLF5 in NIH3T3 cells leads to an increase in the promoter activity of the genes encoding cyclin B1 and Cdc2 [4].


  1. Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene. Ziemer, L.T., Pennica, D., Levine, A.J. Mol. Cell. Biol. (2001) [Pubmed]
  2. A transforming growth factor-beta control element required for SM alpha-actin expression in vivo also partially mediates GKLF-dependent transcriptional repression. Liu, Y., Sinha, S., Owens, G. J. Biol. Chem. (2003) [Pubmed]
  3. Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis. Sur, I., Rozell, B., Jaks, V., Bergström, A., Toftgård, R. J. Cell. Sci. (2006) [Pubmed]
  4. Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation. Nandan, M.O., Chanchevalap, S., Dalton, W.B., Yang, V.W. FEBS Lett. (2005) [Pubmed]
  5. Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. Yang, Y., Goldstein, B.G., Nakagawa, H., Katz, J.P. FASEB J. (2007) [Pubmed]
  6. Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5. Ohnishi, S., Laub, F., Matsumoto, N., Asaka, M., Ramirez, F., Yoshida, T., Terada, M. Dev. Dyn. (2000) [Pubmed]
  7. Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells. Chanchevalap, S., Nandan, M.O., McConnell, B.B., Charrier, L., Merlin, D., Katz, J.P., Yang, V.W. Nucleic Acids Res. (2006) [Pubmed]
  8. Low-level arsenite activates the transcription of genes involved in adipose differentiation. Salazard, B., Bellon, L., Jean, S., Maraninchi, M., El-Yazidi, C., Orsière, T., Margotat, A., Botta, A., Bergé-Lefranc, J.L. Cell Biol. Toxicol. (2004) [Pubmed]
  9. Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. Yang, Y., Tetreault, M.P., Yermolina, Y.A., Goldstein, B.G., Katz, J.P. J. Biol. Chem. (2008) [Pubmed]
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