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Gene Review

hrpB  -  regulatory HRPB transcription regulator...

Ralstonia solanacearum GMI1000

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Disease relevance of hrpB

  • The ability of Ralstonia solanacearum strain GMI1000 to cause disease on a wide range of host plants (including most Solanaceae and Arabidopsis thaliana) depends on genes activated by the regulatory gene hrpB [1].
  • An hrpXv mutant could be partially complemented by the related hrpB gene of Burkholderia solanacearum, the protein product of which shows 40 and 58% amino acid identity and similarity, respectively, to HrpXv [2].

High impact information on hrpB

  • This contact-dependent induction of hrpB gene expression requires the outer membrane protein PrhA, but not a functional type III secretion apparatus [3].
  • We also identified two novel hrpB-regulated genes, hpaZ and hpaB, downstream of hrpY in the hrp cluster [4].
  • In order to isolate type III-related pathogenicity genes, we screened hrpB-regulated genes in R. solanacearum [4].
  • Using a transposon-based system, we isolated 30 novel hpx (hrpB-dependent expression) genes outside the hrp gene cluster [4].
  • Expression of the popABC operon is controlled by the hrpB regulatory gene and is induced upon co-culture with Arabidopsis cell suspensions [5].

Biological context of hrpB


Other interactions of hrpB

  • This indicates that bacterial multiplication at root infection sites and transit through the endodermis constitute critical stages in the infection process, in which hrpB and hrpG genes are involved [7].


  1. Inventory and functional analysis of the large Hrp regulon in Ralstonia solanacearum: identification of novel effector proteins translocated to plant host cells through the type III secretion system. Cunnac, S., Occhialini, A., Barberis, P., Boucher, C., Genin, S. Mol. Microbiol. (2004) [Pubmed]
  2. HrpXv, an AraC-type regulator, activates expression of five of the six loci in the hrp cluster of Xanthomonas campestris pv. vesicatoria. Wengelnik, K., Bonas, U. J. Bacteriol. (1996) [Pubmed]
  3. A bacterial sensor of plant cell contact controls the transcriptional induction of Ralstonia solanacearum pathogenicity genes. Aldon, D., Brito, B., Boucher, C., Genin, S. EMBO J. (2000) [Pubmed]
  4. Genetic screening of Hrp type III-related pathogenicity genes controlled by the HrpB transcriptional activator in Ralstonia solanacearum. Mukaihara, T., Tamura, N., Murata, Y., Iwabuchi, M. Mol. Microbiol. (2004) [Pubmed]
  5. Two novel proteins, PopB, which has functional nuclear localization signals, and PopC, which has a large leucine-rich repeat domain, are secreted through the hrp-secretion apparatus of Ralstonia solanacearum. Guéneron, M., Timmers, A.C., Boucher, C., Arlat, M. Mol. Microbiol. (2000) [Pubmed]
  6. prhJ and hrpG, two new components of the plant signal-dependent regulatory cascade controlled by PrhA in Ralstonia solanacearum. Brito, B., Marenda, M., Barberis, P., Boucher, C., Genin, S. Mol. Microbiol. (1999) [Pubmed]
  7. The hrpB and hrpG regulatory genes of Ralstonia solanacearum are required for different stages of the tomato root infection process. Vasse, J., Genin, S., Frey, P., Boucher, C., Brito, B. Mol. Plant Microbe Interact. (2000) [Pubmed]
  8. Identification of two novel hrp-associated genes in the hrp gene cluster of Xanthomonas oryzae pv. oryzae. Zhu, W., MaGbanua, M.M., White, F.F. J. Bacteriol. (2000) [Pubmed]
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