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Cacna1d  -  calcium channel, voltage-dependent, L type...

Mus musculus

Synonyms: 8430418G19Rik, C79217, Cach3, Cacn4, Cacnl1a2, ...
 
 
 
 
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High impact information on Cacna1d

  • In wild-type controls, D-LTCC-mediated currents showed low activation thresholds and slow inactivation kinetics [1].
  • Therefore, we generated D-LTCC deficient mice (alpha1D-/-) that were viable with no major disturbances of glucose metabolism. alpha1D-/-mice were deaf due to the complete absence of L-type currents in cochlear inner hair cells and degeneration of outer and inner hair cells [1].

References

  1. Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels. Platzer, J., Engel, J., Schrott-Fischer, A., Stephan, K., Bova, S., Chen, H., Zheng, H., Striessnig, J. Cell (2000) [Pubmed]
 
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