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Gene Review:

phbC - POLY3-hydroxybutyrate polymerase

Sinorhizobium meliloti 1021

Willis, L.B. et al., Wang, C. et al., Aneja, P. et al.

Wang, Saldanha, Sheng, Shelswell, Walsh, Sobral, Charles,

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Disease relevance of phbC

Defined insertion mutations have been constructed in the Rhizobium (Sinorhizobium) meliloti phbC gene, which encodes poly-beta-hydroxybutyrate (PHB) synthase [1].
The locus was isolated and subcloned from a genomic library of R. meliloti Rm1021 by complementation of phbC mutation of Alcaligenes eutrophus [1].

High impact information on phbC

Exopolysaccharide (EPS) was not detected in any of the phbC mutants, while the glgA1 and glgA2 mutants produced levels of EPS similar to the wild-type [2].
The competitive abilities of Sinorhizobium meliloti mutant strains containing lesions in the PHB synthesis (phbC) and degradation (bdhA) pathways were compared [3].
The DNA sequence of the R. meliloti phbC gene was determined [1].

Other interactions of phbC

PHB was not detectable in any of the mutants containing the phbC mutation; glycogen was not detectable in any of the mutants containing the glgA1 mutation [2].

References

The phbC (poly-beta-hydroxybutyrate synthase) gene of Rhizobium (Sinorhizobium) meliloti and characterization of phbC mutants. Willis, L.B., Walker, G.C. Can. J. Microbiol. (1998) [Pubmed]
Roles of poly-3-hydroxybutyrate (PHB) and glycogen in symbiosis of Sinorhizobium meliloti with Medicago sp. Wang, C., Saldanha, M., Sheng, X., Shelswell, K.J., Walsh, K.T., Sobral, B.W., Charles, T.C. Microbiology (Reading, Engl.) (2007) [Pubmed]
Comparison of the symbiotic and competition phenotypes of Sinorhizobium meliloti PHB synthesis and degradation pathway mutants. Aneja, P., Zachertowska, A., Charles, T.C. Can. J. Microbiol. (2005) [Pubmed]

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