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Gene Review

exoK  -  endo-beta-1,3-1,4-glycanase

Sinorhizobium meliloti 1021

 
 
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Disease relevance of exoK

  • When grown on medium supplemented with the succinoglycan-binding dye, Calcofluor, and visualized under UV light, colonies of Rhizobium meliloti (Sinorhizobium meliloti) exoK mutants produce a fluorescent halo with a delayed onset relative to wild-type colonies [1].
  • Analysis of the Rhizobium meliloti exoH/exoK/exoL fragment: ExoK shows homology to excreted endo-beta-1,3-1,4-glucanases and ExoH resembles membrane proteins [2].
  • The exoK gene product is characterized by a putative signal peptide and exhibits significant homology to endo-beta-1,3-1,4-glucanases of bacilli and Clostridium thermocellum [2].
 

High impact information on exoK

  • For both wild-type and exoZ mutant strains, production of LMW succinoglycan is dependent on the exoK+ and exsH+ genes, implying that the ExoK and ExsH glycanases cleave HMW succinoglycan to yield LMW succinoglycan [3].
  • Mutants carrying mutations in two of these complementation groups (exoK and exoN) formed apparently normal, nitrogen-fixing nodules, while mutants in the other two groups (exoG and exoJ) formed normal nodules less efficiently than the wild type [4].
  • Nucleotide sequencing of a 4.15 kb DNA fragment from megaplasmid 2 of Rhizobium meliloti 2011 revealed the location of the genes exoH, exoK and exoL [2].

References

 
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