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Gene Review:

yopN - YopN

Yersinia enterocolitica W22703

Iriarte, M. et al., Cheng, L.W. et al., Jackson, M.W. et al., Bogdanove, A.J. et al.

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Disease relevance of yopN

Erwinia amylovora secretes harpin via a type III pathway and contains a homolog of yopN of Yersinia spp [1].

High impact information on yopN

Our results suggest that TyeA forms part of the translocation-control apparatus together with YopD and YopN, and that the interaction of these proteins is required for selective translocation of Yops inside eukaryotic cells [2].
TyeA was found to interact with the translocator YopD and with residues 242-293 of YopN [2].
Two proteins, YopN and LcrG, are known to be involved in Yop-secretion control [2].
Expression of plasmid-borne yopN, but not of yopN(1-294)-npt, complements the calcium-blind phenotype of yopN mutants [3].

Other interactions of yopN

Like YopN, TyeA is localized at the bacterial surface [2].

Analytical, diagnostic and therapeutic context of yopN

Protein cross-linking and immunoprecipitation studies demonstrated a specific interaction between YscB and YopN [4].

References

Erwinia amylovora secretes harpin via a type III pathway and contains a homolog of yopN of Yersinia spp. Bogdanove, A.J., Wei, Z.M., Zhao, L., Beer, S.V. J. Bacteriol. (1996) [Pubmed]
TyeA, a protein involved in control of Yop release and in translocation of Yersinia Yop effectors. Iriarte, M., Sory, M.P., Boland, A., Boyd, A.P., Mills, S.D., Lambermont, I., Cornelis, G.R. EMBO J. (1998) [Pubmed]
Regulated secretion of YopN by the type III machinery of Yersinia enterocolitica. Cheng, L.W., Kay, O., Schneewind, O. J. Bacteriol. (2001) [Pubmed]
YscB of Yersinia pestis functions as a specific chaperone for YopN. Jackson, M.W., Day, J.B., Plano, G.V. J. Bacteriol. (1998) [Pubmed]

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