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Gene Review:

yopH - Yop effector YopH

Yersinia enterocolitica W22703

Guan, K.L. et al., Deleuil, F. et al., Stainier, I. et al., Yao, T. et al.

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Disease relevance of yopH

Suppression of T and B lymphocyte activation by a Yersinia pseudotuberculosis virulence factor, yopH [1].
Yersinia pestis, the bacterium which causes the bubonic plague, also contains a gene closely related to yopH [2].
The vaccinia virus VH1 gene, like yopH in the Yersinia bacteria, encodes a protein phosphatase [2].

High impact information on yopH

Overexpression of yscM1 drastically reduced the expression of a yopH-cat reporter gene when tested in a pYV+ background [3].
These yopH mutants were also clearly attenuated in virulence, showing that binding to p130Cas and/or Fyb is biologically relevant in Yersinia infections [4].

References

Suppression of T and B lymphocyte activation by a Yersinia pseudotuberculosis virulence factor, yopH. Yao, T., Mecsas, J., Healy, J.I., Falkow, S., Chien, Y. J. Exp. Med. (1999) [Pubmed]
Bacterial and viral protein tyrosine phosphatases. Guan, K.L., Dixon, J.E. Semin. Cell Biol. (1993) [Pubmed]
YscM1 and YscM2, two Yersinia enterocolitica proteins causing downregulation of yop transcription. Stainier, I., Iriarte, M., Cornelis, G.R. Mol. Microbiol. (1997) [Pubmed]
Interaction between the Yersinia protein tyrosine phosphatase YopH and eukaryotic Cas/Fyb is an important virulence mechanism. Deleuil, F., Mogemark, L., Francis, M.S., Wolf-Watz, H., Fällman, M. Cell. Microbiol. (2003) [Pubmed]

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