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Gene Review

Cbx3  -  chromobox 3

Mus musculus

Synonyms: Chromobox protein homolog 3, HP1 gamma, HP1g, Heterochromatin protein 1 homolog gamma, M32, ...
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High impact information on Cbx3

  • Furthermore, in the combination chemotherapy model, the interaction between doxorubicin and the resistance modifier 2 was studied in vitro [1].
  • Mice possess two structural homologues of Drosophila HP1, termed M31 and M32 (Singh et al., 1991) [2].
  • Here we report that a MoAb raised against the M32 protein (MAC 385) recognises a 22-kDa protein in murine nuclear extracts and that M32 is distributed in a fine-grain "speckled" pattern within interphase nuclei [2].
  • Of particular interest, mouse blood and MPRO undifferentiated cells and granulocytes revealed clear co-localization of trimethylated H3K9, trimethylated H4K20 and HP1 gamma with pericentric heterochromatin [3].
  • The Cbx3 structural gene is located on mouse Chromosome 6, close to the Hoxa cluster [4].

Biological context of Cbx3

  • The gene and pseudogenes of Cbx3/mHP1 gamma [4].
  • This report presents the isolation and characterization of the 5'-upstream region of the mouse M32 gene containing a promoter region and 5'-untranslated region (5'-UTR) exon [5].


  1. Interaction between doxorubicin and the resistance modifier stilbene on multidrug resistant mouse lymphoma and human breast cancer cells. Ferreira, M.J., Duarte, N., Gy??m??nt, N., Radics, R., Cherepnev, G., Varga, A., Moln??r, J. Anticancer Res. (2006) [Pubmed]
  2. M32, a murine homologue of Drosophila heterochromatin protein 1 (HP1), localises to euchromatin within interphase nuclei and is largely excluded from constitutive heterochromatin. Horsley, D., Hutchings, A., Butcher, G.W., Singh, P.B. Cytogenet. Cell Genet. (1996) [Pubmed]
  3. Granulocyte heterochromatin: defining the epigenome. Olins, D.E., Olins, A.L. BMC Cell Biol. (2005) [Pubmed]
  4. The gene and pseudogenes of Cbx3/mHP1 gamma. Jones, D.O., Mattei, M.G., Horsley, D., Cowell, I.G., Singh, P.B. DNA Seq. (2001) [Pubmed]
  5. Cloning and characterization of 5'-upstream sequence of the M32 gene for a mouse homologue of Drosophila heterochromatin protein 1 (HP1). Sato, M., Miyado, K., Kimura, M. DNA Seq. (2001) [Pubmed]
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