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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cct8  -  chaperonin containing Tcp1, subunit 8 (theta)

Mus musculus

Synonyms: AI132397, CCT-theta, Cctq, T-complex protein 1 subunit theta, TCP-1-theta, ...
 
 
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High impact information on Cct8

  • We analyzed isoelectric variants of the CCT subunits and differences in the peptide mass spectra of two CCT theta isoforms indicated a novel posttranslational modification of this subunit [1].
  • Reporter gene assay using HeLa cells indicated that the Cctq gene promoter contains a cis-acting element of the CCGGAAGT sequence (CQE1) at -36 bp [2].
  • We report here the cloning and the characterization of the Tetrahymena pyriformis chaperonin-containing-TCP1 theta gene (TpCCT theta), an orthologue of the mouse chaperonin gene CCT theta [3].
  • The amino acid sequence of TpCCT theta reveals 39.4-46.0% identity with the sequences of Candida albicans and mouse CCT theta subunits and 28.0-32.6% identity with the other TpCCT subunits known so far [3].

References

  1. Peptide mass fingerprinting of chaperonin-containing TCP-1 (CCT) and copurifying proteins. Hynes, G., Sutton, C.W., U, S., Willison, K.R. FASEB J. (1996) [Pubmed]
  2. Transcriptional regulation of the cytosolic chaperonin theta subunit gene, Cctq, by Ets domain transcription factors Elk-1, Sap-1a, and Net in the absence of serum response factor. Yamazaki, Y., Kubota, H., Nozaki, M., Nagata, K. J. Biol. Chem. (2003) [Pubmed]
  3. Structure of Tetrahymena CCT theta gene and its expression under colchicine treatment. Domingues, C., Soares, H., Rodrigues-Pousada, C., Cyrne, L. Biochim. Biophys. Acta (1999) [Pubmed]
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