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Gene Review

Cd22  -  CD22 antigen

Mus musculus

Synonyms: A530093D23, B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Lyb-8, ...
 
 
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Disease relevance of Cd22

  • Taken together, these results suggest that a lower up-regulation of CD22 on activated B cells (resulting from Cd22 gene anomaly in Cd22a mice or from CD22 heterozygosity in mutants obtained by gene targeting) is implicated in autoantibody production, providing support for Cd22a as a possible candidate allele contributing to lupus susceptibility [1].
  • The monoclonal antibodies alpha S-HCL 1 (alpha Leu-14) and alpha S-HCL 3 (alpha Leu-M5) allow the diagnosis of hairy cell leukemia [2].
  • Antibody targeted therapeutics for lymphoma: new focus on the CD22 antigen and RNA [3].
 

High impact information on Cd22

  • Here we report that mice deficient in both CD22 and its ligand (Cd22-/- St6gal1-/- mice) showed restored B cell receptor (BCR) signaling, suggesting that the suppressed signaling of St6gal1-/- cells is mediated through CD22 [4].
  • Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies [5].
  • Many B-cell malignancies express the CD22 antigen on their cell surface [6].
  • Likewise, detergent-stable FcRgamma association with FcalphaRI was also dependent on Leu-14 and Leu-21 and in addition required residues Tyr-17, Tyr-25, and Cys-26 [7].
  • FcRgamma residue Leu-21 was essential for surface expression of FcepsilonRIalpha/gamma2 and Tyr-8, Leu-14, and Phe-15 contributed to expression [7].
 

Biological context of Cd22

  • Organization of the murine Cd22 locus. Mapping to chromosome 7 and characterization of two alleles [8].
  • Digestion of genomic DNA preparations with four restriction endonucleases revealed the presence of restriction fragment length polymorphisms (RFLP) in BALB/c, C57BL/6, and C3H strains vs DBA/2J, NZB, and NZC strains, suggesting the presence of two or more Cd22 alleles [8].
  • Finally, the study of C57BL/6 Cd22 congenic mice revealed that Cd22a B cells displayed a phenotype reminiscent of constitutively activated B cells (reduced surface IgM expression and augmented MHC class II expression), as reported for B cells expressing a mutant CD22 lacking the ligand-binding domain [9].
  • The Cd22 gene encodes a B cell-specific adhesion molecule that modulates B cell Ag receptor-mediated signal transduction, and is allelic to a lupus-susceptibility locus in New Zealand White (NZW) mice [1].
  • The KD values of the Leu-insertion peptides for competitive binding versus 125I-GRP (2-50 nM) were as potent as parent ... Leu14 agonists [10].
 

Anatomical context of Cd22

  • Southern analysis on genomic DNA isolated from tissues and cell lines from several mouse strains using mCD22 cDNA demonstrated that the Cd22 locus encoding mCD22 is a single copy gene of < or = 30 kb [8].
  • [D-Phe6 psi Leu13-Leu14] Bn(6-14)NH2 was a potent antagonist (Ki 6nM) in Swiss 3T3 cells and guinea pig acini but exhibited 10% partial agonist activity and lower binding affinity (Ki 60 nM) in rat acini [11].
 

Other interactions of Cd22

  • They are negative for IgM, B-220, BP-1, J11d, Lyb8, Ia, F4/80, BP-2, and Mac-1 surface markers [12].
 

Analytical, diagnostic and therapeutic context of Cd22

  • Recently, molecular cloning of the murine CD22 equivalent revealed this molecule to be the same as the previously described Lyb8 alloantigen [13].

References

  1. Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice. Mary, C., Laporte, C., Parzy, D., Santiago, M.L., Stefani, F., Lajaunias, F., Parkhouse, R.M., O'Keefe, T.L., Neuberger, M.S., Izui, S., Reininger, L. J. Immunol. (2000) [Pubmed]
  2. The monoclonal antibodies alpha S-HCL 1 (alpha Leu-14) and alpha S-HCL 3 (alpha Leu-M5) allow the diagnosis of hairy cell leukemia. Schwarting, R., Stein, H., Wang, C.Y. Blood (1985) [Pubmed]
  3. Antibody targeted therapeutics for lymphoma: new focus on the CD22 antigen and RNA. Newton, D.L., Ryback, S.M. Expert opinion on biological therapy. (2001) [Pubmed]
  4. Ablation of CD22 in ligand-deficient mice restores B cell receptor signaling. Collins, B.E., Smith, B.A., Bengtson, P., Paulson, J.C. Nat. Immunol. (2006) [Pubmed]
  5. Inhibition of the B cell by CD22: a requirement for Lyn. Smith, K.G., Tarlinton, D.M., Doody, G.M., Hibbs, M.L., Fearon, D.T. J. Exp. Med. (1998) [Pubmed]
  6. Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors. Mansfield, E., Amlot, P., Pastan, I., FitzGerald, D.J. Blood (1997) [Pubmed]
  7. A common site of the Fc receptor gamma subunit interacts with the unrelated immunoreceptors FcalphaRI and FcepsilonRI. Wines, B.D., Trist, H.M., Ramsland, P.A., Hogarth, P.M. J. Biol. Chem. (2006) [Pubmed]
  8. Organization of the murine Cd22 locus. Mapping to chromosome 7 and characterization of two alleles. Law, C.L., Torres, R.M., Sundberg, H.A., Parkhouse, R.M., Brannan, C.I., Copeland, N.G., Jenkins, N.A., Clark, E.A. J. Immunol. (1993) [Pubmed]
  9. Expression of aberrant forms of CD22 on B lymphocytes in Cd22a lupus-prone mice affects ligand binding. Nitschke, L., Lajaunias, F., Moll, T., Ho, L., Martinez-Soria, E., Kikuchi, S., Santiago-Raber, M.L., Dix, C., Parkhouse, R.M., Izui, S. Int. Immunol. (2006) [Pubmed]
  10. Conveyance of partial agonism/antagonism to bombesin/gastrin-releasing peptide analogues on Swiss 3T3 cells by a carboxyl-terminal leucine insertion. Kull, F.C., Leban, J.J., Landavazo, A., Stewart, K.D., Stockstill, B., McDermed, J.D. J. Biol. Chem. (1992) [Pubmed]
  11. Systematic development of bombesin/gastrin-releasing peptide antagonists. Coy, D.H., Jensen, R.T., Jiang, N.Y., Lin, J.T., Bogden, A.E., Moreau, J.P. J. Natl. Cancer Inst. Monographs (1992) [Pubmed]
  12. LD1: a CD4-CD8- TCR alpha beta/CD3+ peripheral T cell line with helper function for B lymphocytes. Pelkonen, J., Palacios, R. Int. Immunol. (1990) [Pubmed]
  13. Differential expression of CD22 (Lyb8) on murine B cells. Erickson, L.D., Tygrett, L.T., Bhatia, S.K., Grabstein, K.H., Waldschmidt, T.J. Int. Immunol. (1996) [Pubmed]
 
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