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Cd69  -  CD69 antigen

Mus musculus

Synonyms: 5830438K24Rik, AI452015, AIM, Early activation antigen CD69, VEA
 
 
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Disease relevance of Cd69

 

High impact information on Cd69

  • The failure of B10.A V+ mice to produce IgG antibodies against VEA was not due to an intrinsic defect of helper T-cell function because these mice produced IgG antivirus antibodies after sc immunization with killed viral vaccine [2].
  • In C57BL mice milk-borne infection with B-tropic murine leukemia virus (V+ denoting positive for milk-transmitted B-tropic virus and V- denoting negative for milk-transmitted B-tropic virus) was accompanied by an antibody response against viral envelope antigens (VEA) [2].
  • Nevertheless, CD69-deficient lymphocytes had a normal proliferative response to different T-cell and B-cell stimuli [5].
  • Together, these observations indicate that CD69 plays a role in B-cell development and suggest that the putative stimulatory activity of this molecule on bone marrow-derived cells may be replaced in vivo by other signal transducing receptors [5].
  • AIM/CD69 is the earliest leukocyte activation antigen and is expressed mainly by activated T, B, and natural killer (NK) cells [5].
 

Biological context of Cd69

  • Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice [5].
  • The engagement of CD69 by specific antibodies induces intracellular signals, including Ca(++) flux, cytokine synthesis, and cell proliferation [5].
  • Segregation analysis of an informative family of hybrids followed by molecular and karyotype studies clearly demonstrated that the locus encoding CD69 antigen mapped to human chromosome 12 [6].
  • A single pulse with hybrid antibodies rescues immature, CD4/8 double-positive thymocytes from their programmed death in vivo, induces expression of the early activation antigen CD69 followed by TcR up-regulation, concomitant down-regulation of CD8 or CD4 and their conversion to functional mature T cells by day 3 [7].
  • When oocytes were injected with spermatozoa preserved in ETBS supplemented with DMSO or VEA/DMSO, chromosome integrity did not decrease significantly (through 9 days of preservation) [8].
 

Anatomical context of Cd69

 

Other interactions of Cd69

 

Analytical, diagnostic and therapeutic context of Cd69

  • Genomic sequence analysis indicates the presence of at least seven members between Nkrpla and Cd69 [11].
  • After about the 125th serial transfer in culture, BALB/c tumor cells spontaneously ceased to express VEA and simultaneously became very weak inducers of transplantation immunity in BALB/c hosts [1].

References

  1. Antigenic properties of cultured tumor cell lines derived from spleens of Friend virus-infected BALB/c and BALB/c-H-2b mice. Freedman, H.A., Lilly, F., Steeves, R.A. J. Exp. Med. (1975) [Pubmed]
  2. Naturally occurring leukemia viruses in H-2 congenic C57BL mice. II. Antibody response to viral envelope antigens. Vlug, A., Melief, C.J., de Bruyne, C., Schoenmakers, H., Molenaar, J.L. J. Natl. Cancer Inst. (1980) [Pubmed]
  3. A subset of CD4+ T cells expressing early activation antigen CD69 in murine lupus: possible abnormal regulatory role for cytokine imbalance. Ishikawa, S., Akakura, S., Abe, M., Terashima, K., Chijiiwa, K., Nishimura, H., Hirose, S., Shirai, T. J. Immunol. (1998) [Pubmed]
  4. The use of transgenic mice for the production of a human monoclonal antibody specific for human CD69 antigen. Molina, A., Valladares, M., Magadán, S., Sancho, D., Viedma, F., Sanjuan, I., Gambón, F., Sánchez-Madrid, F., González-Fernández, A. J. Immunol. Methods (2003) [Pubmed]
  5. Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice. Lauzurica, P., Sancho, D., Torres, M., Albella, B., Marazuela, M., Merino, T., Bueren, J.A., Martínez-A, C., Sánchez-Madrid, F. Blood (2000) [Pubmed]
  6. Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. Cambiaggi, C., Scupoli, M.T., Cestari, T., Gerosa, F., Carra, G., Tridente, G., Accolla, R.S. Immunogenetics (1992) [Pubmed]
  7. T cell receptor targeting to thymic cortical epithelial cells in vivo induces survival, activation and differentiation of immature thymocytes. Müller, K.P., Kyewski, B.A. Eur. J. Immunol. (1993) [Pubmed]
  8. Ability to activate oocytes and chromosome integrity of mouse spermatozoa preserved in EGTA Tris-HCl buffered solution supplemented with antioxidants. Kusakabe, H., Kamiguchi, Y. Theriogenology (2004) [Pubmed]
  9. Expression and function of the early activation antigen CD69 in murine macrophages. Marzio, R., Jirillo, E., Ransijn, A., Mauël, J., Corradin, S.B. J. Leukoc. Biol. (1997) [Pubmed]
  10. Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo. Dawicki, W., Watts, T.H. Eur. J. Immunol. (2004) [Pubmed]
  11. Cloning of Clr, a new family of lectin-like genes localized between mouse Nkrp1a and Cd69. Plougastel, B., Dubbelde, C., Yokoyama, W.M. Immunogenetics (2001) [Pubmed]
 
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