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Gene Review:

araC - DNA-binding transcriptional regulator AraC

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Clarke, P. et al., Lee, J.H. et al.

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Disease relevance of araC

Mutations in the araC gene of Salmonella typhimurium LT2 which affect both activator and auto-regulatory functions of the AraC protein [1].

High impact information on araC

The araC gene encodes a regulatory protein, AraC, that acts as both an activator and a repressor of transcription of the genes involved in the transport and catabolism of L-arabinose in Salmonella typhimurium LT2 [1].
DNA sequence analysis showed that all nine mutations occurred in the araC promoter [2].

References

Mutations in the araC gene of Salmonella typhimurium LT2 which affect both activator and auto-regulatory functions of the AraC protein. Clarke, P., Lee, J.H., Burke, K., Wilcox, G. Gene (1992) [Pubmed]
Mutations resulting in promoter-like sequences which enhance the expression of araC in Salmonella typhimurium. Lee, J.H., Burke, K., Wilcox, G. Gene (1986) [Pubmed]

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