Disease relevance of apeE

• The apeE gene of Salmonella enterica serovar Typhimurium is induced by phosphate limitation and regulated by phoBR [1].
• The apeE gene of Salmonella typhimurium encodes an outer membrane esterase not present in Escherichia coli [2].

High impact information on apeE

• Mutations in apeR, a regulatory locus of the outer membrane esterase apeE from Salmonella enterica serovar Typhimurium, were shown to be alleles of the pstSCAB-phoU high-affinity phosphate transport operon [1].
• Salmonella typhimurium apeR mutations lead to overproduction of an outer membrane-associated N-acetyl phenylalanine beta-naphthyl ester-cleaving esterase that is encoded by the apeE gene (P. Collin-Osdoby and C. G. Miller, Mol. Gen. Genet. 243:674-680, 1994) [2].
• We report that the apeE gene product is the enzyme in Salmonella uniquely responsible for the hydrolysis of this substrate [2].
• The apeE locus is P1 cotransducible with purE (12 map units) [3].

Analytical, diagnostic and therapeutic context of apeE

• Southern blot analysis indicates that Escherichia coli K-12 does not contain a close analog of apeE, and it appears that the apeE gene is contained in a region of DNA present in Salmonella but not in E. coli [2].

References