Disease relevance of motB

• Torque generation in the flagellar motor of Escherichia coli: evidence of a direct role for FliG but not for FliM or FliN [1].
• Geometry of the flagellar motor in the cytoplasmic membrane of Salmonella typhimurium as determined by stereo-photogrammetry of quick-freeze deep-etch replica images [2].

High impact information on motB

• The 15th suppressor from the original selection and 2 motB suppressors identified during a subsequent search cause single amino acid substitutions in FliG [3].
• To study interactions between the Mot proteins themselves and between them and other components of the flagellar motor, we attempted to isolate extragenic suppressors of 13 dominant or partially dominant motB missense mutations [3].
• Impressive progress has been made in understanding the mechanism of bacterial chemotaxis and function of the flagellar motor, but how the direction of rotation is reversed by the 'flagellar switch'--a central step in chemotaxis--remains obscure and calls for new experimental approaches [4].
• The specificity of fumarate as a switching factor of the bacterial flagellar motor [5].
• Preparations from mutant strains show that the presence of these features does not depend on the presence of the motA, motB or cheA genes [6].

Biological context of motB

• Correlation between phosphorylation of the chemotaxis protein CheY and its activity at the flagellar motor [7].
• A spontaneous fliL mutant of S. typhimurium, containing a frameshift mutation about 40% from the 3' end of the gene, was moderately motile but swarmed poorly, suggesting that FliL might be a component of the flagellar motor or switch [8].

Associations of motB with chemical compounds

• Within this complex, the receptor regulates the autophosphorylation activity of histidine kinase CheA, thereby controlling the signals sent to the flagellar motor and the receptor adaptation system [9].

Other interactions of motB

• All of the second-site mutations in motA and motB caused some impairment of motility, both in the pseudorevertants and in a wild-type fliG background [10].

References