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Gene Review

CNGA2  -  cyclic nucleotide gated channel alpha 2

Homo sapiens

Synonyms: CNCA, CNCA1, CNCG2, CNG channel alpha-2, CNG-2, ...
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High impact information on CNGA2

  • Here, we report on the stable reconstitution of OR-specific signaling in HeLa/Olf cells via G protein alphaolf and adenylyl cyclase type-III to the Ca2+ influx-mediating olfactory cyclic nucleotide-gated CNGA2 channel [1].
  • Recent evidence shows that three subunit types (CNGA2, CNGA4, and CNGB1b) make up native olfactory CNG channels and account for the fast inhibition of native channels by Ca2+/CaM [2].
  • A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel [3].
  • We also report the generation and characterization of a stably transfected PDE9 Chinese hamster ovary cell line, additionally expressing soluble guanylate cyclase (sGC), the olfactory cyclic nucleotide-gated cation channel CNGA2 and the photoprotein aequorin [4].
  • Recordings from membrane patches excised from CNGA2-expressing HEK 293 cells revealed that cholesterol depletion dramatically reduced the apparent affinity of homomeric CNGA2 channels for cAMP but only slightly reduced the maximal current [5].

Anatomical context of CNGA2


Associations of CNGA2 with chemical compounds


Physical interactions of CNGA2

  • Studies using chimeric channels revealed that transplantation of the pore domain from CNGA2 was sufficient to confer high affinity PsTx binding upon a CNGA3 background [10].

Analytical, diagnostic and therapeutic context of CNGA2


  1. Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants. Shirokova, E., Schmiedeberg, K., Bedner, P., Niessen, H., Willecke, K., Raguse, J.D., Meyerhof, W., Krautwurst, D. J. Biol. Chem. (2005) [Pubmed]
  2. Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels. Trudeau, M.C., Zagotta, W.N. J. Biol. Chem. (2003) [Pubmed]
  3. A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel. Qu, W., Moorhouse, A.J., Chandra, M., Pierce, K.D., Lewis, T.M., Barry, P.H. J. Gen. Physiol. (2006) [Pubmed]
  4. Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line. Wunder, F., Tersteegen, A., Rebmann, A., Erb, C., Fahrig, T., Hendrix, M. Mol. Pharmacol. (2005) [Pubmed]
  5. Functional role of lipid raft microdomains in cyclic nucleotide-gated channel activation. Brady, J.D., Rich, T.C., Le, X., Stafford, K., Fowler, C.J., Lynch, L., Karpen, J.W., Brown, R.L., Martens, J.R. Mol. Pharmacol. (2004) [Pubmed]
  6. Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues. Cheng, K.T., Chan, F.L., Huang, Y., Chan, W.Y., Yao, X. Histochem. Cell Biol. (2003) [Pubmed]
  7. [7-(Dialkylamino)coumarin-4-yl]methyl-Caged Compounds as Ultrafast and Effective Long-Wavelength Phototriggers of 8-Bromo-Substituted Cyclic Nucleotides. Hagen, V., Frings, S., Wiesner, B., Helm, S., Kaupp, U.B., Bendig, J. Chembiochem (2003) [Pubmed]
  8. Mutation of the pore glutamate affects both cytoplasmic and external dequalinium block in the rat olfactory CNGA2 channel. Qu, W., Moorhouse, A.J., Lewis, T.M., Pierce, K.D., Barry, P.H. Eur. Biophys. J. (2005) [Pubmed]
  9. Resolution of cAMP signals in three-dimensional microdomains using novel, real-time sensors. Karpen, J.W., Rich, T.C. Proc. West. Pharmacol. Soc. (2004) [Pubmed]
  10. Pseudechetoxin binds to the pore turret of cyclic nucleotide-gated ion channels. Brown, R.L., Lynch, L.L., Haley, T.L., Arsanjani, R. J. Gen. Physiol. (2003) [Pubmed]
  11. Bestrophin-2 is a candidate calcium-activated chloride channel involved in olfactory transduction. Pifferi, S., Pascarella, G., Boccaccio, A., Mazzatenta, A., Gustincich, S., Menini, A., Zucchelli, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  12. A cell-based nitric oxide reporter assay useful for the identification and characterization of modulators of the nitric oxide/guanosine 3',5'-cyclic monophosphate pathway. Wunder, F., Buehler, G., Hüser, J., Mundt, S., Bechem, M., Kalthof, B. Anal. Biochem. (2007) [Pubmed]
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