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Ovgp1  -  oviductal glycoprotein 1

Mus musculus

Synonyms: 120kDa, AU016433, AU019448, Chit5, Estrogen-dependent oviduct protein, ...
 
 
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Disease relevance of Ovgp1

 

High impact information on Ovgp1

  • The presence of oviductin in the rabbit endocervix indicates this glycoprotein may have multiple functions, and it can no longer be considered oviduct-specific [2].
  • Intraovarian oocytes do not contain this glycoprotein and we demonstrate here that the immunoaffinity-purified oviductin readily binds to their zonae pellucidae in vitro, thus mimicking the in vivo phenomenon [3].
  • Collectively, these results suggest that the hamster oviductin polymorphism observed in two-dimensional PAGE is a consequence of different glycosylation patterns and not the polypeptide chain itself [3].
  • We propose that hamster oviductin is a mucin-type glycoprotein which might act as a protective secretion influencing the first steps of the reproductive process necessary for the normal triggering of fertilization and early embryonic development [3].
  • Even though OGP has been shown to interact with gametes and the early embryo, the protein's direct function has not yet been established [4].
 

Biological context of Ovgp1

  • To understand the fundamental mechanisms that direct gene expression as well as to know the physiological significance of OGP, we have isolated and characterized a mouse OGP gene (mogp-1) [5].
  • It was also inferred that the mature MOGP contained three potential N-linked glycosylation sites and 24 possible O-linked glycosylation sites, and had the unique seven-residue repeat sequence (21 repeats) within the predicted sequence in the C-terminal side [6].
  • OGP binding sites on the head and tail region of monkey sperm could be demonstrated by using antibody against rOGP [4].
  • In the present study, we have isolated the cDNA for the mouse oviduct-specific glycoprotein (MOGP) by screening the mouse oviduct cDNA library with the bovine oviduct-specific glycoprotein (BOGP)-cDNA probe and by the 5' rapid amplification of the cDNA end (5'RACE) [6].
  • The amino acid sequence of a portion of MOGP was highly homologous to that of BOGP (71% identity), baboon oviduct-specific glycoprotein (61% identity), and human oviduct-specific glycoprotein (77% identity) [6].
 

Anatomical context of Ovgp1

 

Associations of Ovgp1 with chemical compounds

  • The mammalian estrogen induced oviductal glycoprotein (OGP) has been known to associate with capacitated sperm, oocytes and developing embryos [8].
 

Other interactions of Ovgp1

  • A member of the chitinase protein family, oviduct-specific glycoprotein (OGP), can directly associate with gametes or with the early embryo in the oviduct [5].
 

Analytical, diagnostic and therapeutic context of Ovgp1

References

  1. Mouse transgenic for murine oviduct-specific glycoprotein promoter-driven simian virus 40 large T-antigen: tumor formation and its hormonal regulation. Miyoshi, I., Takahashi, K., Kon, Y., Okamura, T., Mototani, Y., Araki, Y., Kasai, N. Mol. Reprod. Dev. (2002) [Pubmed]
  2. Oviductin (Muc9) is expressed in rabbit endocervix. Hendrix, E., Hewetson, A., Mansharamani, M., Chilton, B.S. Endocrinology (2001) [Pubmed]
  3. Biochemical characterization of hamster oviductin as a sulphated zona pellucida-binding glycoprotein. Malette, B., Bleau, G. Biochem. J. (1993) [Pubmed]
  4. Overexpression of monkey oviductal protein: purification and characterization of recombinant protein and its antibodies. Natraj, U., Bhatt, P., Vanage, G., Moodbidri, S.B. Biol. Reprod. (2002) [Pubmed]
  5. Mouse oviduct-specific glycoprotein gene: genomic organization and structure of the 5'-flanking regulatory region. Takahashi, K., Sendai, Y., Matsuda, Y., Hoshi, H., Hiroi, M., Araki, Y. Biol. Reprod. (2000) [Pubmed]
  6. Molecular cloning and characterization of a mouse oviduct-specific glycoprotein. Sendai, Y., Komiya, H., Suzuki, K., Onuma, T., Kikuchi, M., Hoshi, H., Araki, Y. Biol. Reprod. (1995) [Pubmed]
  7. Effect of a null mutation of the oviduct-specific glycoprotein gene on mouse fertilization. Araki, Y., Nohara, M., Yoshida-Komiya, H., Kuramochi, T., Ito, M., Hoshi, H., Shinkai, Y., Sendai, Y. Biochem. J. (2003) [Pubmed]
  8. Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9. Kadam, K.M., D'Souza, S.J., Bandivdekar, A.H., Natraj, U. Mol. Hum. Reprod. (2006) [Pubmed]
 
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