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Gene Review

FCRLB  -  Fc receptor-like B

Homo sapiens

Synonyms: FCRL2, FCRLM2, FCRLY, FCRY, FLJ31052, ...
 
 
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High impact information on FCRLB

  • The isolation of a novel Fc receptor (FcRY) from chicken yolk sac provides insight at the mechanistic level as to how avian maternal immunoglobulin (IgY) is transferred to offspring [1].
  • A consistent characteristic of FcRY in both species is low level gene expression, which can be further downregulated in normal mouse B cells by signaling through the B cell receptor (BCR) or CD40, thereby suggesting a correlation between cell cycle entrance and diminished FcRY expression [2].
  • FcRY is also expressed in subpopulations of human B cells [2].
  • The predicted protein lacks a hydrophobic domain for insertion into the plasma membrane, suggesting that FcRY is an intracellular or secreted protein [2].
  • A bioinformatics approach has lead to the identification of FcRY, a new Fc receptor related gene [2].

References

  1. Acquiring maternal immunoglobulin; different receptors, similar functions. Ward, E.S. Immunity (2004) [Pubmed]
  2. FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. Masuda, K., Davis, R.S., Maruyama, T., Zhang, J., He, T., Cooper, M.D., O-Wang, J., Burrows, P.D. Gene (2005) [Pubmed]
 
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