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Gene Review

Csn3  -  casein kappa

Mus musculus

Synonyms: AW208918, CSN10, Csn10, Csnk, Kappa-casein
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High impact information on Csn3

  • In view of the extreme structural conservation of the casein locus, as well as the phenotype of Csnk-/- females, we propose that the organization of a functional kappa-casein gene would have been one of the critical events in the evolution of mammals [1].
  • To understand the role of kappa-casein in lactation, we have created and characterized a null mouse strain (Csnk-/-) lacking this gene [1].
  • Nucleotide sequences for the kappa-casein precursor proteins have been determined from the genomic DNAs or hair roots of the Ruminantia [2].


  1. kappa-casein-deficient mice fail to lactate. Shekar, P.C., Goel, S., Rani, S.D., Sarathi, D.P., Alex, J.L., Singh, S., Kumar, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Molecular phylogeny based on the kappa-casein and cytochrome b sequences in the mammalian suborder Ruminantia. Chikuni, K., Mori, Y., Tabata, T., Saito, M., Monma, M., Kosugiyama, M. J. Mol. Evol. (1995) [Pubmed]
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