Disease relevance of Dad1

• CONCLUSION: These results suggest the involvement of the Dad1 gene in the acquisition of a common syndactyly phenotype, as well as in the control of programmed cell death during development [1].

Psychiatry related information on Dad1

• In the current study the effects of DAD1- and DAD2-like agonists on motor activity of C57BL/6 (C57) mice were determined to establish species consistencies and differences with respect to their effects on rats [2].

High impact information on Dad1

• A targeted mutation at the T-cell receptor alpha/delta locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dad1 [3].
• Our analysis further reveals that the antiapoptosis gene Dad1 is at the 3' end of the TCR alpha/delta locus and that Dad1 is required for embryogenesis [3].
• We show that mouse Dad1 has a broader expression pattern than the TCR genes, in terms of both tissue and temporal specificity [3].
• The DAD1 protein disappeared in tsBN7 cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggers apoptosis [4].
• By comparing the base sequences of the parental BHK21 and tsBN7 DAD1 cDNAs, we found that the DAD1-encoding gene is mutated in tsBN7 cells [4].

Biological context of Dad1

• The Dad1 protein has been shown to play a role in prevention of apoptosis in certain cell types [5].
• Dad1 is also a subunit of the oligosaccharyltransferase enzyme complex that initiates N-linked glycosylation [5].
• Function and factor interactions of a locus control region element in the mouse T cell receptor-alpha/Dad1 gene locus [6].
• 5. Thus, Dad1 is required for proper processing of N-linked glycoproteins and for certain cell survival in the mouse [7].
• Abnormalities of developmental cell death in Dad1-deficient mice [1].

Anatomical context of Dad1

• Transgenic mice that overexpress Dad1 in both the thymus and peripheral immune system have been generated [5].
• Dad1 has been shown to play a role in preventing apoptotic cell death and in regulating levels of N-linked glycosylation in Saccharomyces cerevisiae and the BHK hamster cell line [7].
• In an in vitro blastocyst culture system, Dad1-null cells displayed abnormalities which were comparable to those obtained in vivo [1].

Associations of Dad1 with chemical compounds

• The partial DAD1-like agonist SKF 38393 reduced the activity of C57 mice at low doses and elevated activity above control levels at higher doses, if the mice were thoroughly habituated to the test chamber [2].

Other interactions of Dad1

• In hamster BHK21-derived tsBN7 cells, loss of Dad1 causes apoptosis which cannot be prevented by Bcl-2 [1].

Analytical, diagnostic and therapeutic context of Dad1

• RESULTS: To determine the role of Dad1 function in vivo, we prepared by gene targeting, mice harbouring a disrupted Dad1 gene [1].

References