Gene Review:
Gadd45a - growth arrest and DNA-damage-inducible 45...
Mus musculus
Synonyms:
AA545191, DDIT-1, DNA damage-inducible transcript 1 protein, Ddit1, GADD45, ...
- Transcriptional up-regulation of Gadd45a in Patched-associated medulloblastoma. Kappler, R., Hess, I., Schlegel, J., Hahn, H. Int. J. Oncol. (2004)
- Gadd45a acts as a modifier locus for lymphoblastic lymphoma. Hollander, M.C., Patterson, A.D., Salvador, J.M., Anver, M.R., Hunger, S.P., Fornace, A.J. Leukemia (2005)
- Loss of Gadd45a does not modify the pulmonary response to oxidative stress. Roper, J.M., Gehen, S.C., Staversky, R.J., Hollander, M.C., Fornace, A.J., O'Reilly, M.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2005)
- Gadd45a Suppresses Ras-Driven Mammary Tumorigenesis by Activation of c-Jun NH2-Terminal Kinase and p38 Stress Signaling Resulting in Apoptosis and Senescence. Tront, J.S., Hoffman, B., Liebermann, D.A. Cancer Res. (2006)
- Genomic instability in Gadd45a-deficient mice. Hollander, M.C., Sheikh, M.S., Bulavin, D.V., Lundgren, K., Augeri-Henmueller, L., Shehee, R., Molinaro, T.A., Kim, K.E., Tolosa, E., Ashwell, J.D., Rosenberg, M.P., Zhan, Q., Fernández-Salguero, P.M., Morgan, W.F., Deng, C.X., Fornace, A.J. Nat. Genet. (1999)
- Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Salvador, J.M., Hollander, M.C., Nguyen, A.T., Kopp, J.B., Barisoni, L., Moore, J.K., Ashwell, J.D., Fornace, A.J. Immunity (2002)
- Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins. Price, B.D., Calderwood, S.K. Cancer Res. (1992)
- Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a. Bulavin, D.V., Kovalsky, O., Hollander, M.C., Fornace, A.J. Mol. Cell. Biol. (2003)
- Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development. Bishop, A.J., Hollander, M.C., Kosaras, B., Sidman, R.L., Fornace, A.J., Schiestl, R.H. Cancer Res. (2003)
- Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition. Gupta, M., Gupta, S.K., Hoffman, B., Liebermann, D.A. J. Biol. Chem. (2006)
- Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation. Hildesheim, J., Belova, G.I., Tyner, S.D., Zhou, X., Vardanian, L., Fornace, A.J. Oncogene (2004)
- Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. Wang, X., Wang, R.H., Li, W., Xu, X., Hollander, M.C., Fornace, A.J., Deng, C.X. J. Biol. Chem. (2004)
- GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. Vairapandi, M., Balliet, A.G., Hoffman, B., Liebermann, D.A. J. Cell. Physiol. (2002)
- Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells. Cai, Q., Dmitrieva, N.I., Ferraris, J.D., Michea, L.F., Salvador, J.M., Hollander, M.C., Fornace, A.J., Fenton, R.A., Burg, M.B. Am. J. Physiol. Renal Physiol. (2006)
- Genomic instability in Gadd45a-/- cells is coupled with S-phase checkpoint defects. Hollander, M.C., Philburn, R.T., Patterson, A.D., Wyatt, M.A., Fornace, A.J. Cell Cycle (2005)
- CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. Chung, H.K., Yi, Y.W., Jung, N.C., Kim, D., Suh, J.M., Kim, H., Park, K.C., Song, J.H., Kim, D.W., Hwang, E.S., Yoon, S.H., Bae, Y.S., Kim, J.M., Bae, I., Shong, M. J. Biol. Chem. (2003)
- Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells. Chakravarty, D., Cai, Q., Ferraris, J.D., Michea, L., Burg, M.B., Kültz, D. Am. J. Physiol. Renal Physiol. (2002)
- Gadd45a contributes to p53 stabilization in response to DNA damage. Jin, S., Mazzacurati, L., Zhu, X., Tong, T., Song, Y., Shujuan, S., Petrik, K.L., Rajasekaran, B., Wu, M., Zhan, Q. Oncogene (2003)
- Loss of p21WAF1/Cip1 in Gadd45-deficient keratinocytes restores DNA repair capacity. Maeda, T., Espino, R.A., Chomey, E.G., Luong, L., Bano, A., Meakins, D., Tron, V.A. Carcinogenesis (2005)
- Stress-induced JNK activation is independent of Gadd45 induction. Shaulian, E., Karin, M. J. Biol. Chem. (1999)
- Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency. Hollander, M.C., Kovalsky, O., Salvador, J.M., Kim, K.E., Patterson, A.D., Haines, D.C., Fornace, A.J. Cancer Res. (2001)
- NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Zerbini, L.F., Wang, Y., Czibere, A., Correa, R.G., Cho, J.Y., Ijiri, K., Wei, W., Joseph, M., Gu, X., Grall, F., Goldring, M.B., Zhou, J.R., Libermann, T.A., Zhou, J.R. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress. Mak, S.K., Kültz, D. J. Biol. Chem. (2004)
- Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1. Kearsey, J.M., Coates, P.J., Prescott, A.R., Warbrick, E., Hall, P.A. Oncogene (1995)