Disease relevance of Darc

• Despite this, the susceptibility to Staphylococcus aureus infection was the same in the absence and in the presence of gp-Fy [1].
• The only significant difference between Dfy(-/-) and Dfy(+/+) mice that we found was in neutrophil migration in peritoneal inflammations induced by lipopolysaccharide and thioglycolate [1].

High impact information on Darc

• The mouse Duffy gene (Dfy) homolog of human FY is also a single-copy gene, which maps in a region of conserved synteny with FY and produces a glycoprotein with 60% homology to the human protein [1].
• Our results indicate that gp-Fy is functionally a redundant protein that may participate in the neutrophil migratory process [1].
• In bone marrow and spleen, Dfy expresses a major 1.4-kb and a minor 1.8-kb mRNA [2].
• Sequence analyses indicate that Dfy consists of two exons: exon 1 of 55 nucleotides, which encodes 7 amino acid residues; and exon 2 of 1038 nucleotides, which encodes 327 residues [2].
• It is a single copy gene located in chromosome 1 in a region homologous to the human Duffy gene (FY) [2].

Biological context of Darc

• Recipient serum samples were also tested against human RBCs of various Fy phenotypes [3].
• The effects of RA on S14 and GPD gene transcription in cultured adipocytes suggest that RA action may extend beyond growth and differentiation to include effects on lipid metabolism [4].

Anatomical context of Darc

• The production of red blood cell alloantibodies in mice transfused with blood from transgenic Fy-expressing mice [3].

References