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Gene Review:

parB - putative partition protein

Pseudomonas putida

Bartosik, A.A. et al., Sevastsyanovich, Y.R. et al.

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Disease relevance of parB

Dissection of the pM3 mini-replicon, pMT2, showed that this replication deficiency in E. coli is suppressed by additional determinants from its par operon: ParB, which can be supplied in trans, and its target, the par operon promoter, required in cis to ori V-rep [1].
Purified ParB binds specifically to DNA containing a putative parS sequence based on the consensus sequence found in the chromosomes of Bacillus subtilis, Pseudomonas putida, and Streptomyces coelicolor [2].

High impact information on parB

The dimerization domain of P. aeruginosa ParB is interchangeable with the dimerization domain of KorB from plasmid RK2 (IncP1 group) [2].

References

Ability of IncP-9 plasmid pM3 to replicate in Escherichia coli is dependent on both rep and par functions. Sevastsyanovich, Y.R., Titok, M.A., Krasowiak, R., Bingle, L.E., Thomas, C.M. Mol. Microbiol. (2005) [Pubmed]
ParB of Pseudomonas aeruginosa: interactions with its partner ParA and its target parS and specific effects on bacterial growth. Bartosik, A.A., Lasocki, K., Mierzejewska, J., Thomas, C.M., Jagura-Burdzy, G. J. Bacteriol. (2004) [Pubmed]

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