Gene Review:
Dpp4 - dipeptidylpeptidase 4
Mus musculus
Synonyms:
Cd26, DPP IV, Dipeptidyl peptidase 4, Dipeptidyl peptidase IV, Dpp-4, ...
Hildebrandt,
Arck,
Kruber,
Demuth,
Reutter,
Klapp,
Green,
Lavery,
Irwin,
O'harte,
Harriott,
Greer,
Bailey,
Flatt,
Rüter,
Hoffmann,
Heiser,
Demuth,
Arck,
Klapp,
Hildebrandt,
Steinbrecher,
Reinhold,
Quigley,
Gado,
Tresser,
Izikson,
Born,
Faust,
Neubert,
Martin,
Ansorge,
Brocke,
Green,
Gault,
O'Harte,
Flatt,
Green,
Irwin,
Flatt,
Gunnarsson,
Winzell,
Deacon,
Larsen,
Jelic,
Carr,
Ahrén,
Yamazaki,
Yasuda,
Inoue,
Yamamoto,
Sugaya,
Nagakura,
Shinoda,
Clark,
Saeki,
Tanaka,
- Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Conarello, S.L., Li, Z., Ronan, J., Roy, R.S., Zhu, L., Jiang, G., Liu, F., Woods, J., Zycband, E., Moller, D.E., Thornberry, N.A., Zhang, B.B. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Evidence that thymocyte-activating molecule is mouse CD26 (dipeptidyl peptidase IV). Vivier, I., Marguet, D., Naquet, P., Bonicel, J., Black, D., Li, C.X., Bernard, A.M., Gorvel, J.P., Pierres, M. J. Immunol. (1991)
- The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency. Richard, E., Arredondo-Vega, F.X., Santisteban, I., Kelly, S.J., Patel, D.D., Hershfield, M.S. J. Exp. Med. (2000)
- Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Marguet, D., Baggio, L., Kobayashi, T., Bernard, A.M., Pierres, M., Nielsen, P.F., Ribel, U., Watanabe, T., Drucker, D.J., Wagtmann, N. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Purification and characterization of mouse fetal liver epithelial cells with high in vivo repopulation capacity. Nierhoff, D., Ogawa, A., Oertel, M., Chen, Y.Q., Shafritz, D.A. Hepatology (2005)
- Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo. Steinbrecher, A., Reinhold, D., Quigley, L., Gado, A., Tresser, N., Izikson, L., Born, I., Faust, J., Neubert, K., Martin, R., Ansorge, S., Brocke, S. J. Immunol. (2001)
- Redistribution of glomerular dipeptidyl peptidase type IV in experimental lupus nephritis. Demonstration of decreased enzyme activity at the ultrastructural level. van Leer, E.H., Bruijn, J.A., Prins, F.A., Hoedemaeker, P.J., de Heer, E. Lab. Invest. (1993)
- Effects of the Combination of a Dipeptidyl Peptidase IV Inhibitor and an Insulin Secretagogue on Glucose and Insulin Levels in Mice and Rats. Yamazaki, K., Yasuda, N., Inoue, T., Yamamoto, E., Sugaya, Y., Nagakura, T., Shinoda, M., Clark, R., Saeki, T., Tanaka, I. J. Pharmacol. Exp. Ther. (2007)
- Structure of the mouse dipeptidyl peptidase IV (CD26) gene. Bernard, A.M., Mattei, M.G., Pierres, M., Marguet, D. Biochemistry (1994)
- Pituitary adenylate cyclase-activating peptide (PACAP): assessment of dipeptidyl peptidase IV degradation, insulin-releasing activity and antidiabetic potential. Green, B.D., Irwin, N., Flatt, P.R. Peptides (2006)
- Dipeptide proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha). Gilmore, B.F., Lynas, J.F., Scott, C.J., McGoohan, C., Martin, L., Walker, B. Biochem. Biophys. Res. Commun. (2006)
- Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases. David, F., Bernard, A.M., Pierres, M., Marguet, D. J. Biol. Chem. (1993)
- cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases. Marguet, D., Bernard, A.M., Vivier, I., Darmoul, D., Naquet, P., Pierres, M. J. Biol. Chem. (1992)
- Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and protein in mice. Gunnarsson, P.T., Winzell, M.S., Deacon, C.F., Larsen, M.O., Jelic, K., Carr, R.D., Ahrén, B. Endocrinology (2006)
- Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice. Green, B.D., Lavery, K.S., Irwin, N., O'harte, F.P., Harriott, P., Greer, B., Bailey, C.J., Flatt, P.R. J. Pharmacol. Exp. Ther. (2006)
- CD26 is essential for normal G-CSF-induced progenitor cell mobilization as determined by CD26-/- mice. Christopherson, K.W., Cooper, S., Hangoc, G., Broxmeyer, H.E. Exp. Hematol. (2003)
- PEGylated glucagon-like peptide-1 displays preserved effects on insulin release in isolated pancreatic islets and improved biological activity in db/db mice. Lee, S., Youn, Y.S., Lee, S.H., Byun, Y., Lee, K.C. Diabetologia (2006)
- A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Green, B.D., Gault, V.A., O'Harte, F.P., Flatt, P.R. Diabetes, obesity & metabolism. (2005)
- Inhibition of dipeptidyl peptidase IV (DP IV, CD26) activity abrogates stress-induced, cytokine-mediated murine abortions. Hildebrandt, M., Arck, P.C., Kruber, S., Demuth, H.U., Reutter, W., Klapp, B.F. Scand. J. Immunol. (2001)
- Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. Parker, J.C., Lavery, K.S., Irwin, N., Green, B.D., Greer, B., Harriott, P., O'harte, F.P., Gault, V.A., Flatt, P.R. J. Endocrinol. (2006)
- Altered small intestinal absorptive enzyme activities in leptin-deficient obese mice: influence of bowel resection. Kiely, J.M., Noh, J.H., Svatek, C.L., Pitt, H.A., Swartz-Basile, D.A. J. Pediatr. Surg. (2006)
- Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice. Rüter, J., Hoffmann, T., Demuth, H.U., Moschansky, P., Klapp, B.F., Hildebrandt, M. Biol. Chem. (2004)
- The expression of T-cell surface antigens CTLA-4, CD26, and CD28 is modulated by inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity in murine stress-induced abortions. Rüter, J., Hoffmann, T., Heiser, U., Demuth, H.U., Arck, P.C., Klapp, B.F., Hildebrandt, M. Cell. Immunol. (2002)
- Quantitative gene expression analysis reveals transition of fetal liver progenitor cells to mature hepatocytes after transplantation in uPA/RAG-2 mice. Cantz, T., Zuckerman, D.M., Burda, M.R., Dandri, M., Göricke, B., Thalhammer, S., Heckl, W.M., Manns, M.P., Petersen, J., Ott, M. Am. J. Pathol. (2003)