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Gene Review

NOBOX  -  NOBOX oogenesis homeobox

Homo sapiens

Synonyms: Homeobox protein NOBOX, OG-2, OG2, OG2X, Og2x, ...
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High impact information on NOBOX

  • These results suggest that NOBOX directly regulates the transcription of Pou5f1 and Gdf9 in oocytes during early folliculogenesis [1].
  • In addition, we found that promoter regions of mouse Pou5f1 and Gdf9 contain one (-426) and three NOBOX binding elements (-786, -967, and -1259), respectively [1].
  • Factor in the germline (Figla) and newborn ovary homeobox gene (Nobox) represent a growing number of oocyte-specific transcription factors that regulate genes unique to oocytes [2].
  • Nobox is a homeobox gene that is preferentially expressed in the oocytes and is essential for folliculogenesis and the regulation of oocyte-specific gene expression in the mouse [3].
  • Germ cell-specific transcription factors such as Figla and Nobox are critical in oogenesis, while Zfp148 and Taf4b are also critical in spermatogenesis [4].

Biological context of NOBOX

  • Our data suggest that mutations of the homeobox region of the NOBOX gene are uncommon in Japanese patients with POF [5].
  • No mutations in exons 2-6 of the NOBOX gene, including the homeobox region, could be identified in Japanese women with POF [5].

Other interactions of NOBOX


Analytical, diagnostic and therapeutic context of NOBOX


  1. Characterization of NOBOX DNA Binding Specificity and Its Regulation of Gdf9 and Pou5f1 Promoters. Choi, Y., Rajkovic, A. J. Biol. Chem. (2006) [Pubmed]
  2. Transcriptional regulation of early oogenesis: in search of masters. Pangas, S.A., Rajkovic, A. Hum. Reprod. Update (2006) [Pubmed]
  3. cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles. Huntriss, J., Hinkins, M., Picton, H.M. Mol. Hum. Reprod. (2006) [Pubmed]
  4. Sohlh2 is a germ cell-specific bHLH transcription factor. Ballow, D.J., Xin, Y., Choi, Y., Pangas, S.A., Rajkovic, A. Gene Expr. Patterns (2006) [Pubmed]
  5. Mutational analysis of the homeobox region of the human NOBOX gene in Japanese women who exhibit premature ovarian failure. Zhao, X.X., Suzumori, N., Yamaguchi, M., Suzumori, K. Fertil. Steril. (2005) [Pubmed]
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