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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Edv  -  endogenous sequence related to the Duplan...

Mus musculus

Synonyms: murine leukemia virus gag, pol, and env pseudogene
 
 
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Disease relevance of Edv

  • Therefore, the amino acid sequence of the defective MAIDS virus p12gag region is not homologous to that of the helper virus and the Edv transcript because of the frameshift [1].
  • These results suggest that the mutagenic DNA synthesis is involved in murine thymic lymphoma genesis, although mutation of the pol beta gene is not a major causal event [2].
  • Although p48 is the most conserved subunit of mammalian DNA polymerase alpha-primase (pol-prim), the polypeptide is the major species-specific factor for mouse polyomavirus (PyV) DNA replication [3].
  • We have constructed hybrid retrovirus packaging cell lines that express the gibbon ape leukemia virus env and the Moloney murine leukemia virus gag-pol proteins [4].
  • HIV replication efficiencies of six different drug-resistant site-directed mutants were reproducibly quantified and were similar to those obtained with a growth competition assay in which the relative proportion of each variant was measured by sequence analysis, indicating that recombination between the pol and reporter genes was negligible [5].
 

High impact information on Edv

  • We showed previously that pol mu participates in light chain but surprisingly not heavy chain gene rearrangement [6].
  • We report the complete absence of A/T mutations in MSH2-pol eta double-deficient mice, thus indicating that the residual A/T mutagenesis in MSH2-deficient mice is contributed by pol eta, now recruited by uracil N-glycosylase, the second DNA repair pathway involved in hypermutation [7].
  • Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2-MSH6 proteins, together with DNA polymerase eta (pol eta) [7].
  • DNA polymerase kappa (pol kappa) is a member of the Y-family of DNA polymerases that are thought to function in translesion synthesis (TLS) past different types of DNA damage [8].
  • At the coding region, H3 acetylation and dimethylation, as well as pol II binding, are found in cells at later stages of differentiation, when apM1 transcription reaches its maximal peak [9].
 

Biological context of Edv

  • These results suggested that the MAIDS virus was generated by frameshift mutations in the p12gag region of Edv or a related sequence [1].
  • Compared with the nucleotide sequence of the helper LP-BM5 ecotropic virus, the pathogenic replication-defective MAIDS virus has a 16-bp deletion and a 1-bp insertion in the 5' and 3' regions of the p12gag sequence, respectively, and the Edv transcript contains only a 3-bp deletion [1].
  • A detailed study of the apM1 locus shows that H3-K4 dimethylation is restricted to the promoter region in undifferentiated cells and associates with RNA polymerase II (pol II) loading [9].
  • The activity of TFIIIC1 strongly enhances specific binding of basal pol III factors TFIIIA, TFIIIC2 and the PSE binding protein (PBP) to their cognate promoter elements and it acts independently of the corresponding termination regions [10].
  • Retroviral genomes encoding a portion of the Moloney murine leukemia virus Gag protein fused to portions of the murine axl cDNA were constructed so as to mimic naturally occurring transforming viruses [11].
 

Anatomical context of Edv

 

Associations of Edv with chemical compounds

 

Analytical, diagnostic and therapeutic context of Edv

  • A polyprotein of molecular weight 120,000 (p120) containing murine leukemia virus gag gene determinants was invariably deteced by immunoprecipitation analysis of individual transformants induced by the 7.8-kilobase-pair DNA [15].
  • Quantitative real-time PCR (QPCR) TaqMan-based assays for HML groups 1-7, targeting the conserved reverse transcriptase (RT) and integrase (IN) domains of the pol gene were designed [16].

References

  1. Possible origin of murine AIDS (MAIDS) virus: conversion of an endogenous retroviral p12gag sequence to a MAIDS-inducing sequence by frameshift mutations. Kubo, Y., Kakimi, K., Higo, K., Kobayashi, H., Ono, T., Iwama, Y., Kuribayashi, K., Hiai, H., Adachi, A., Ishimoto, A. J. Virol. (1996) [Pubmed]
  2. Reduced fidelity of DNA synthesis in cell extracts from chemically induced primary thymic lymphomas of mice. Kubota, Y., Murakami-Murofushi, K., Shimada, Y., Ogiu, T., Oikawa, T. Cancer Res. (1995) [Pubmed]
  3. Amino acids 257 to 288 of mouse p48 control the cooperation of polyomavirus large T antigen, replication protein A, and DNA polymerase alpha-primase to synthesize DNA in vitro. Kautz, A.R., Weisshart, K., Schneider, A., Grosse, F., Nasheuer, H.P. J. Virol. (2001) [Pubmed]
  4. Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus. Miller, A.D., Garcia, J.V., von Suhr, N., Lynch, C.M., Wilson, C., Eiden, M.V. J. Virol. (1991) [Pubmed]
  5. Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture. Dykes, C., Wang, J., Jin, X., Planelles, V., An, D.S., Tallo, A., Huang, Y., Wu, H., Demeter, L.M. J. Clin. Microbiol. (2006) [Pubmed]
  6. Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo. Bertocci, B., De Smet, A., Weill, J.C., Reynaud, C.A. Immunity (2006) [Pubmed]
  7. DNA polymerase {eta} is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. Delbos, F., Aoufouchi, S., Faili, A., Weill, J.C., Reynaud, C.A. J. Exp. Med. (2007) [Pubmed]
  8. The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair. Ogi, T., Lehmann, A.R. Nat. Cell Biol. (2006) [Pubmed]
  9. Histone H3 lysine 4 dimethylation signals the transcriptional competence of the adiponectin promoter in preadipocytes. Musri, M.M., Corominola, H., Casamitjana, R., Gomis, R., Párrizas, M. J. Biol. Chem. (2006) [Pubmed]
  10. Human transcription factors IIIC2 , IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes. Oettel, S., Härtel, F., Kober, I., Iben, S., Seifart, K.H. Nucleic Acids Res. (1997) [Pubmed]
  11. Transforming activity of retroviral genomes encoding Gag-Axl fusion proteins. Zhang, Q.K., Boast, S., de los Santos, K., Begemann, M., Goff, S.P. J. Virol. (1996) [Pubmed]
  12. Association of murine leukemia virus gag antigen with extracellular matrices in productively infected mouse cells. Edwards, S.A., Lin, Y.C., Fan, H. Virology (1982) [Pubmed]
  13. HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells. Ross, M.J., Fan, C., Ross, M.D., Chu, T.H., Shi, Y., Kaufman, L., Zhang, W., Klotman, M.E., Klotman, P.E. J. Acquir. Immune Defic. Syndr. (2006) [Pubmed]
  14. Point mutations in the P30 domain of the gag gene of Moloney murine leukemia virus. Hsu, H.W., Schwartzberg, P., Goff, S.P. Virology (1985) [Pubmed]
  15. Abelson murine leukemia virus: molecular cloning of infectious integrated proviral DNA. Srinivasan, A., Reddy, E.P., Aaronson, S.A. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  16. Development of real-time PCRs for detection and quantitation of human MMTV-like (HML) sequences HML expression in human tissues. Muradrasoli, S., Forsman, A., Hu, L., Blikstad, V., Blomberg, J. J. Virol. Methods (2006) [Pubmed]
 
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