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Eif4ebp2  -  eukaryotic translation initiation factor...

Mus musculus

Synonyms: 2810011I19Rik, 4E-BP2, AA792569, BC010348, Eukaryotic translation initiation factor 4E-binding protein 2, ...
 
 
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Disease relevance of Eif4ebp2

  • We report that the combined disruption of 4E-BP1 and 4E-BP2 in mice increased their sensitivity to diet-induced obesity [1].
 

Psychiatry related information on Eif4ebp2

 

High impact information on Eif4ebp2

  • Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2 [1].
  • A related protein, PHAS-II, and eIF4E were readily detectable in tissues from these animals, but neither appeared to be changed in a compensatory manner [4].
  • Unlike PHAS-I, PHAS-II was readily phosphorylated by cAMP-dependent protein kinase in vitro; however, the effects of insulin on both PHAS proteins were attenuated by agents that increase intracellular cAMP, by cAMP derivatives, and by phosphodiesterase inhibitors [5].
  • The 4E-BP2 gene spans approximately 20 kb and exhibits an identical genomic organization to that of 4E-BP1, with the protein coding portion of the gene divided into three exons [6].
  • In order to determine how translation initiation is regulated during neuroplasticity we engineered mutant C57Bl/6J mice that lack the translation repressor eukaryotic initiation factor 4E-binding protein 2 (4E-BP2) and have previously demonstrated that 4E-BP2 plays a critical role in hippocampus-dependent synaptic plasticity and memory [3].
 

Biological context of Eif4ebp2

 

Anatomical context of Eif4ebp2

  • Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes [5].
  • These results suggest a crucial role for proper regulation of the eIF4F complex by 4E-BP2 during LTP and learning and memory in the mouse hippocampus [2].
 

Physical interactions of Eif4ebp2

  • 4E-binding protein 1 (BP1) and 4E-BP2 are small proteins that bind to eIF4E and inhibit translation [7].

References

  1. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. Le Bacquer, O., Petroulakis, E., Paglialunga, S., Poulin, F., Richard, D., Cianflone, K., Sonenberg, N. J. Clin. Invest. (2007) [Pubmed]
  2. The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. Banko, J.L., Poulin, F., Hou, L., DeMaria, C.T., Sonenberg, N., Klann, E. J. Neurosci. (2005) [Pubmed]
  3. Behavioral alterations in mice lacking the translation repressor 4E-BP2. Banko, J.L., Merhav, M., Stern, E., Sonenberg, N., Rosenblum, K., Klann, E. Neurobiology of learning and memory (2007) [Pubmed]
  4. Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice. Blackshear, P.J., Stumpo, D.J., Carballo, E., Lawrence, J.C. J. Biol. Chem. (1997) [Pubmed]
  5. Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes. Lin, T.A., Lawrence, J.C. J. Biol. Chem. (1996) [Pubmed]
  6. Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. Tsukiyama-Kohara, K., Vidal, S.M., Gingras, A.C., Glover, T.W., Hanash, S.M., Heng, H., Sonenberg, N. Genomics (1996) [Pubmed]
  7. The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth. Rousseau, D., Gingras, A.C., Pause, A., Sonenberg, N. Oncogene (1996) [Pubmed]
 
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