High impact information on Emr1

• EGF-TM7: a novel subfamily of seven-transmembrane-region leukocyte cell-surface molecules [1].
• The epidermal growth factor-seven transmembrane (EGF-TM7) family is a group of seven-span transmembrane receptors predominantly expressed by cells of the immune system [2].
• The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense [2].
• EGF-TM7 receptors bind cellular ligands as demonstrated by the interaction of CD97 with decay accelerating factor (CD55) and dermatan sulfate [2].
• Genetic mapping established that mEMR4 is localized in the distal region of mouse chromosome 17 in close proximity to another EGF-TM7 gene, F4/80 (Emr1) [3].

Biological context of Emr1

• Functional analysis of the murine Emr1 promoter identifies a novel purine-rich regulatory motif required for high-level gene expression in macrophages [4].
• This study has investigated the transcriptional regulation of the Emr1 gene in murine macrophages and defined an enhancer element within the proximal promoter that is necessary for Emr1 expression in myeloid cells [4].
• Within the large TM7 superfamily, the molecular structure and ligand-binding properties of EGF-TM7 receptors are unique [5].
• These members of the EGF-TM7 family are characterized by a variable number of NH2-terminal EGF domains and seven transmembrane-spanning hydrophobic regions, which demonstrate a degree of sequence homology to the corresponding region in members of the G-protein-coupled peptide hormone receptor family [6].
• Based on an analysis of the recently unraveled genome, the EGF-TM7 family of the rat is described here [7].

Other interactions of Emr1

• By flow cytometry analysis, WP-3.27 is Thy-1lo, Lyt-1+ (CD5+), but CD3-, TCR-alpha beta-, and TCR-gamma delta-. Moreover, WP-3.27 does not express surface immunoglobulins but expresses B220 (CD45RA), and also some macrophage markers such as Mac-1, F4-80, and MHC class II after gamma-IFN treatment [8].

References