Disease relevance of Epha3

• On the other hand, ETK-1 xenografts were diagnosed as tubular adenocarcinoma, and the tumor cells had a ductal phenotype [1].

High impact information on Epha3

• Binding activity detected with alkaline phosphatase fusions of ELF-1 and Mek4 also reveals gradients and provides direct evidence for molecular complementarity of gradients in reciprocal fields [2].
• Mek4 and Sek are tyrosine kinases with expression patterns in the mouse embryo that suggest important functions in early development [3].
• The expression domains of ELF-1, Mek4 and Sek indicate potential roles in embryonic patterning [3].
• By comparison, Mek4 showed no significant transcription in the ES cell cultures by Northern analysis, whereas Eck displayed stronger signals in ES cells than in the embryoid bodies [4].
• This suggests the possibility that ETK-1 cells can differentiate along a biliary epithelial cell lineage [1].

Anatomical context of Epha3

• Our results extend the purported role of Mek4 in axon guidance to include motor neurons of the medial motor column [5].
• Mek4 has previously been ascribed a role in guiding retinal axons to their targets in the optic tectum [5].
• The ETK-1 cells appeared to be converted into hepatocytes by exposure to 5-azaCR [1].
• In this study, a human sarcomatoid CC cell line, ETK-1, was established from a patient, and then morphological and phenotypical characteristics of the ETK-1 cells were evaluated before and after treatment with differentiation-inducing 5-azacytidine (5-azaCR) [1].

Other interactions of Epha3

• We show that Mek4 and Sek soluble receptor-alkaline phosphatase fusion proteins can be used in a procedure termed RAP in situ to identify regions of ligand expression in the mouse embryo [3].

Analytical, diagnostic and therapeutic context of Epha3

• We present sequence analysis that identifies Tyro4 as the rat homolog of mouse Mek4 and chick Cek4 [5].

References