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Gene Review

exed  -  extraembryonic ectoderm development

Mus musculus

 
 
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High impact information on exed

  • Previous complementation analyses with five (c11DSD, c5FR60Hg, c2YPSj, c4FR60Hd, c6H) of the mouse albino deletions defined at least two genes on chromosome 7, known as eed and exed, which are necessary for development of the embryonic and extraembryonic ectoderm, respectively, of early postimplantation embryos [1].
  • The extraembryonic ectoderm development (exed) mutant phenotype was described in mice homozygous for the c(6H) deletion, a radiation-induced deletion in the tyrosinase region of mouse Chromosome 7 [2].
  • We then sequenced the 20-kb exed-critical region and no expressed exons were found [2].
  • Taken together, these results indicate that the exed phenotype may either be a position effect on a distal gene caused by the c(6H) breakpoint or the result of composite effects of nullizygosity of multiple genes in the deletion homozygotes [2].
  • The fit1 locus, which is currently defined by five N-ethyl-N-nitrosourea (ENU)-induced mutations, was found to map in a subregion between the eed and exed loci [3].
 

Biological context of exed

  • The resulting mice homozygous for this deletion were viable and fertile, indicating that the 20-kb exed-critical region by itself is not sufficient to cause the phenotype when deleted [2].

References

  1. The albino-deletion complex of the mouse: molecular mapping of deletion breakpoints that define regions necessary for development of the embryonic and extraembryonic ectoderm. Sharan, S.K., Holdener-Kenny, B., Ruppert, S., Schedl, A., Kelsey, G., Rinchik, E.M., Magnuson, T. Genetics (1991) [Pubmed]
  2. Genetic analysis of the exed region in mouse. Kendall, S.K., Strong, S.J., Litman, R.T., Litman, G.W., Magnuson, T. Genesis (2000) [Pubmed]
  3. Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7. Potter, M.D., Klebig, M.L., Carpenter, D.A., Rinchik, E.M. Mamm. Genome (1995) [Pubmed]
 
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