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Gene Review

F5  -  coagulation factor V

Mus musculus

Synonyms: AI173222, Activated protein C cofactor, Cf-5, Cf5, Coagulation factor V
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Disease relevance of F5


High impact information on F5

  • Coagulation factor V is a critical cofactor for the activation of prothrombin to thrombin, the penultimate step in the generation of a fibrin blood clot [2].
  • Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V [2].
  • Coagulation factor V in bone marrow was detected by simultaneous immunofluorescent staining with polyclonal burro anti-human factor V antibody or with a panel of murine monoclonal anti-human factor V antibodies [3].
  • The effects of CpG1826 were evaluated in a system where a population of NP68-specific F5 TCR transgenic CD8 T cells is diluted into a polyclonal host following adoptive transfer into C57BL/10 syngeneic recipients [4].
  • In contrast, RU486 had no effect on thymic apoptosis induced by the influenza A nucleoprotein NP366-374 peptide, recognized in context of Db, in F5 TCR transgenic mice [5].

Biological context of F5


Anatomical context of F5


Associations of F5 with chemical compounds


Other interactions of F5


Analytical, diagnostic and therapeutic context of F5


  1. Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Cui, J., Eitzman, D.T., Westrick, R.J., Christie, P.D., Xu, Z.J., Yang, A.Y., Purkayastha, A.A., Yang, T.L., Metz, A.L., Gallagher, K.P., Tyson, J.A., Rosenberg, R.D., Ginsburg, D. Blood (2000) [Pubmed]
  2. Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Cui, J., O'Shea, K.S., Purkayastha, A., Saunders, T.L., Ginsburg, D. Nature (1996) [Pubmed]
  3. Identification of human megakaryocyte coagulation factor V. Nichols, W.L., Gastineau, D.A., Solberg, L.A., Mann, K.G. Blood (1985) [Pubmed]
  4. In vivo impact of CpG1826 oligodeoxynucleotide on CD8 T cell primary responses and survival. Beloeil, L., Tomkowiak, M., Angelov, G., Walzer, T., Dubois, P., Marvel, J. J. Immunol. (2003) [Pubmed]
  5. Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice. Xue, Y., Murdjeva, M., Okret, S., McConkey, D., Kiuossis, D., Jondal, M. Eur. J. Immunol. (1996) [Pubmed]
  6. Assignment of gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in rat. Dahlbäck, B., Hansson, C., Islam, M.Q., Szpirer, J., Szpirer, C., Lundwall, A., Levan, G. Somat. Cell Mol. Genet. (1988) [Pubmed]
  7. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Mamalaki, C., Elliott, J., Norton, T., Yannoutsos, N., Townsend, A.R., Chandler, P., Simpson, E., Kioussis, D. Dev. Immunol. (1993) [Pubmed]
  8. Tolerant CD8 T cells induced by multiple injections of peptide antigen show impaired TCR signaling and altered proliferative responses in vitro and in vivo. Dubois, P.M., Pihlgren, M., Tomkowiak, M., Van Mechelen, M., Marvel, J. J. Immunol. (1998) [Pubmed]
  9. Estrogen increases coagulation factor V mRNA levels via both estrogen receptor-alpha and -beta in murine bone marrow/bone. Movérare, S., Skrtic, S., Lindberg, M.K., Dahlman-Wright, K., Ohlsson, C. Eur. J. Endocrinol. (2004) [Pubmed]
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