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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Fbp2  -  fructose bisphosphatase 2

Mus musculus

Synonyms: D-fructose-1,6-bisphosphate 1-phosphohydrolase 2, FBPase 2, FBPase muscle, Fbp-1, Fbp1, ...
 
 
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High impact information on Fbp2

  • The sequence encodes 519 amino acids and, based on homology to rat heart genomic sequence, appears to be the product of alternative splicing from PFK-2/FBPase-2 gene B with an extended version of exon 15 [1].
  • A 1932 bp cDNA clone encoding a novel isozyme of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFK-2/ FBPase-2) was isolated from a mouse kidney cDNA library [1].
  • In contrast to the liver enzyme, the activity of tumour PFK-2/FBPase-2 is not influenced by the action of cAMP-dependent protein kinase [2].

References

  1. Molecular cloning and tissue-specific expression of mouse kidney 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Batra, R.S., Brown, R., Brown, G.K., Craig, I.W. FEBS Lett. (1996) [Pubmed]
  2. Fructose 2,6-bisphosphate metabolism in Ehrlich ascites tumour cells. Nissler, K., Petermann, H., Wenz, I., Brox, D. J. Cancer Res. Clin. Oncol. (1995) [Pubmed]
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