The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Fes  -  feline sarcoma oncogene

Mus musculus

Synonyms: AI586313, BB137047, FPS, Fps, Proto-oncogene c-Fes, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Fes

 

High impact information on Fes

 

Biological context of Fes

  • There was no association between tumor incidence and genotype at the D7Rp2, Fes, or Int-2 loci [6].
  • Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7 [7].
  • Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase [8].
  • We previously showed that FcepsilonRI aggregation caused a rapid increase in phosphorylation of both Fer and Fps/Fes kinases in bone marrow-derived mast cells [9].
  • This study identifies physiological, cellular, and molecular defects that contribute to the hyperinflammatory phenotype in Fps/Fes null mice [10].
 

Anatomical context of Fes

 

Associations of Fes with chemical compounds

  • Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling [1].
  • Fps/Fes-null mice were healthy and fertile, displayed slightly reduced numbers of bone marrow myeloid progenitors and circulating mature myeloid cells, and were more sensitive to lipopolysaccharide (LPS) [13].
  • Further examination of downstream signaling demonstrates that kinase-inactive Fes inhibits the recruitment of phosphoinositide 3-kinase to the activated IL-4 receptor complex and decreases the activation of p70(S6k) kinase in response to IL-4 [14].
  • The choline phosphate-containing alkyllysophospholipids (ALPs) had little or moderate effect on the proliferation and none on the viability of NIH 3T3 clone 7, and sublines transformed by raf (NIH/9IV #5), fes (Fes 1), src (Src 1) and mos (Mos 1) oncogenes [15].
  • Atipamezole (3 mg/kg), mCPP (3 mg/kg), and h/r-CRF (.3, 1 microg) did not affect FPS, but increased startle independently from the presence of the cue [16].
 

Physical interactions of Fes

  • We have previously shown that 151 base pairs of c-fes 5'-flanking sequences are sufficient for myeloid cell-specific expression and include functional binding sites for Sp1, PU.1, and a novel nuclear factor (Heydemann, A., Juang, G., Hennessy, K., Parmacek, M. S., and Simon, M. C. (1996) Mol. Cell. Biol. 16, 1676-1686) [17].
 

Regulatory relationships of Fes

  • Taken together, our findings suggest that Fes links Sema3A signals to CRMP-CRAM, and that NP-1 negatively regulates PlexA1 activation by Fes in resting condition [1].
  • Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival [18].
  • Using COS-7 cells as a model system, we observed that Fes strongly colocalizes with microtubules in vivo when activated via coiled-coil mutation or by coexpression with an active Src family kinase [19].
  • The myeloid-cell-specific c-fes promoter is regulated by Sp1, PU.1, and a novel transcription factor [20].
 

Other interactions of Fes

 

Analytical, diagnostic and therapeutic context of Fes

References

  1. Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling. Mitsui, N., Inatome, R., Takahashi, S., Goshima, Y., Yamamura, H., Yanagi, S. EMBO J. (2002) [Pubmed]
  2. Activated Fps/Fes partially rescues the in vivo developmental potential of Flk1-deficient vascular progenitor cells. Haigh, J.J., Ema, M., Haigh, K., Gertsenstein, M., Greer, P., Rossant, J., Nagy, A., Wagner, E.F. Blood (2004) [Pubmed]
  3. Human gene (c-fes) related to the onc sequences of Snyder-Theilen feline sarcoma virus. Franchini, G., Gelmann, E.P., Dalla-Favera, R., Gallo, R.C., Wong-Staal, F. Mol. Cell. Biol. (1982) [Pubmed]
  4. Closing in on the biological functions of Fps/Fes and Fer. Greer, P. Nat. Rev. Mol. Cell Biol. (2002) [Pubmed]
  5. Abnormal Stat activation, hematopoietic homeostasis, and innate immunity in c-fes-/- mice. Hackenmiller, R., Kim, J., Feldman, R.A., Simon, M.C. Immunity (2000) [Pubmed]
  6. Localization of a novel chromosome 7 locus that suppresses development of N-Methyl-N-nitrosourea-induced murine thymic lymphomas. Angel, J.M., Morizot, D.C., Richie, E.R. Mol. Carcinog. (1993) [Pubmed]
  7. Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7. Potter, M.D., Klebig, M.L., Carpenter, D.A., Rinchik, E.M. Mamm. Genome (1995) [Pubmed]
  8. Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase. Izuhara, K., Feldman, R.A., Greer, P., Harada, N. Blood (1996) [Pubmed]
  9. Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation. Udell, C.M., Samayawardhena, L.A., Kawakami, Y., Kawakami, T., Craig, A.W. J. Biol. Chem. (2006) [Pubmed]
  10. The Fps/Fes kinase regulates the inflammatory response to endotoxin through down-regulation of TLR4, NF-{kappa}B activation, and TNF-{alpha} secretion in macrophages. Parsons, S.A., Greer, P.A. J. Leukoc. Biol. (2006) [Pubmed]
  11. Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Craig, A.W., Greer, P.A. Mol. Cell. Biol. (2002) [Pubmed]
  12. Insulin-like growth factor I receptor gene is concordant with c-Fes protooncogene and mouse chromosome 7 in somatic cell hybrids. Sundaresan, S., Francke, U. Somat. Cell Mol. Genet. (1989) [Pubmed]
  13. Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis. Zirngibl, R.A., Senis, Y., Greer, P.A. Mol. Cell. Biol. (2002) [Pubmed]
  14. Fes mediates the IL-4 activation of insulin receptor substrate-2 and cellular proliferation. Jiang, H., Foltenyi, K., Kashiwada, M., Donahue, L., Vuong, B., Hehn, B., Rothman, P. J. Immunol. (2001) [Pubmed]
  15. Glycosylated antitumor ether lipids are more effective against oncogene-transformed fibroblasts than alkyllysophospholipids. Samadder, P., Byun, H.S., Bittman, R., Arthur, G. Anticancer Res. (1998) [Pubmed]
  16. Anxiogenic treatments do not increase fear-potentiated startle in mice. Risbrough, V.B., Geyer, M.A. Biol. Psychiatry (2005) [Pubmed]
  17. Expression of two myeloid cell-specific genes requires the novel transcription factor, c-fes expression factor. Heydemann, A., Boehmler, J.H., Simon, M.C. J. Biol. Chem. (1997) [Pubmed]
  18. Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival. Sangrar, W., Gao, Y., Bates, B., Zirngibl, R., Greer, P.A. Exp. Hematol. (2004) [Pubmed]
  19. The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly. Laurent, C.E., Delfino, F.J., Cheng, H.Y., Smithgall, T.E. Mol. Cell. Biol. (2004) [Pubmed]
  20. The myeloid-cell-specific c-fes promoter is regulated by Sp1, PU.1, and a novel transcription factor. Heydemann, A., Juang, G., Hennessy, K., Parmacek, M.S., Simon, M.C. Mol. Cell. Biol. (1996) [Pubmed]
  21. Comparative genetics of albinism. Searle, A.G. Ophthalmic paediatrics and genetics. (1990) [Pubmed]
  22. Fps/Fes and Fer non-receptor protein-tyrosine kinases regulate collagen- and ADP-induced platelet aggregation. Senis, Y.A., Sangrar, W., Zirngibl, R.A., Craig, A.W., Lee, D.H., Greer, P.A. J. Thromb. Haemost. (2003) [Pubmed]
  23. Truncation of c-fes via gene targeting results in embryonic lethality and hyperproliferation of hematopoietic cells. Hackenmiller, R., Simon, M.C. Dev. Biol. (2002) [Pubmed]
  24. Genetic mapping of the mouse oncogenes c-Ha-ras-1 and c-fes to chromosome 7. Kozak, C.A., Sears, J.F., Hoggan, M.D. J. Virol. (1983) [Pubmed]
  25. Microsatellite instability in IVS3 of murine c-fes gene: tumor-associated rearrangement and mammalian divergence. Volpi, L., Beghini, A., Rossi, D., Larizza, L. Mamm. Genome (1996) [Pubmed]
  26. Expression of proto-oncogenes in xenografts of human renal cell carcinomas. Karthaus, H.F., Bussemakers, M.J., Schalken, J.A., Kurth, K.H., Feitz, W.F., Debruyne, F.M., Bloemers, H.P., Van de Ven, W.J. Urol. Res. (1987) [Pubmed]
 
WikiGenes - Universities