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Gene Review

Fes  -  feline sarcoma oncogene

Mus musculus

Synonyms: AI586313, BB137047, FPS, Fps, Proto-oncogene c-Fes, ...
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Disease relevance of Fes


High impact information on Fes


Biological context of Fes

  • There was no association between tumor incidence and genotype at the D7Rp2, Fes, or Int-2 loci [6].
  • Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7 [7].
  • Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase [8].
  • We previously showed that FcepsilonRI aggregation caused a rapid increase in phosphorylation of both Fer and Fps/Fes kinases in bone marrow-derived mast cells [9].
  • This study identifies physiological, cellular, and molecular defects that contribute to the hyperinflammatory phenotype in Fps/Fes null mice [10].

Anatomical context of Fes


Associations of Fes with chemical compounds

  • Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling [1].
  • Fps/Fes-null mice were healthy and fertile, displayed slightly reduced numbers of bone marrow myeloid progenitors and circulating mature myeloid cells, and were more sensitive to lipopolysaccharide (LPS) [13].
  • Further examination of downstream signaling demonstrates that kinase-inactive Fes inhibits the recruitment of phosphoinositide 3-kinase to the activated IL-4 receptor complex and decreases the activation of p70(S6k) kinase in response to IL-4 [14].
  • The choline phosphate-containing alkyllysophospholipids (ALPs) had little or moderate effect on the proliferation and none on the viability of NIH 3T3 clone 7, and sublines transformed by raf (NIH/9IV #5), fes (Fes 1), src (Src 1) and mos (Mos 1) oncogenes [15].
  • Atipamezole (3 mg/kg), mCPP (3 mg/kg), and h/r-CRF (.3, 1 microg) did not affect FPS, but increased startle independently from the presence of the cue [16].

Physical interactions of Fes

  • We have previously shown that 151 base pairs of c-fes 5'-flanking sequences are sufficient for myeloid cell-specific expression and include functional binding sites for Sp1, PU.1, and a novel nuclear factor (Heydemann, A., Juang, G., Hennessy, K., Parmacek, M. S., and Simon, M. C. (1996) Mol. Cell. Biol. 16, 1676-1686) [17].

Regulatory relationships of Fes

  • Taken together, our findings suggest that Fes links Sema3A signals to CRMP-CRAM, and that NP-1 negatively regulates PlexA1 activation by Fes in resting condition [1].
  • Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival [18].
  • Using COS-7 cells as a model system, we observed that Fes strongly colocalizes with microtubules in vivo when activated via coiled-coil mutation or by coexpression with an active Src family kinase [19].
  • The myeloid-cell-specific c-fes promoter is regulated by Sp1, PU.1, and a novel transcription factor [20].

Other interactions of Fes


Analytical, diagnostic and therapeutic context of Fes


  1. Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling. Mitsui, N., Inatome, R., Takahashi, S., Goshima, Y., Yamamura, H., Yanagi, S. EMBO J. (2002) [Pubmed]
  2. Activated Fps/Fes partially rescues the in vivo developmental potential of Flk1-deficient vascular progenitor cells. Haigh, J.J., Ema, M., Haigh, K., Gertsenstein, M., Greer, P., Rossant, J., Nagy, A., Wagner, E.F. Blood (2004) [Pubmed]
  3. Human gene (c-fes) related to the onc sequences of Snyder-Theilen feline sarcoma virus. Franchini, G., Gelmann, E.P., Dalla-Favera, R., Gallo, R.C., Wong-Staal, F. Mol. Cell. Biol. (1982) [Pubmed]
  4. Closing in on the biological functions of Fps/Fes and Fer. Greer, P. Nat. Rev. Mol. Cell Biol. (2002) [Pubmed]
  5. Abnormal Stat activation, hematopoietic homeostasis, and innate immunity in c-fes-/- mice. Hackenmiller, R., Kim, J., Feldman, R.A., Simon, M.C. Immunity (2000) [Pubmed]
  6. Localization of a novel chromosome 7 locus that suppresses development of N-Methyl-N-nitrosourea-induced murine thymic lymphomas. Angel, J.M., Morizot, D.C., Richie, E.R. Mol. Carcinog. (1993) [Pubmed]
  7. Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7. Potter, M.D., Klebig, M.L., Carpenter, D.A., Rinchik, E.M. Mamm. Genome (1995) [Pubmed]
  8. Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase. Izuhara, K., Feldman, R.A., Greer, P., Harada, N. Blood (1996) [Pubmed]
  9. Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation. Udell, C.M., Samayawardhena, L.A., Kawakami, Y., Kawakami, T., Craig, A.W. J. Biol. Chem. (2006) [Pubmed]
  10. The Fps/Fes kinase regulates the inflammatory response to endotoxin through down-regulation of TLR4, NF-{kappa}B activation, and TNF-{alpha} secretion in macrophages. Parsons, S.A., Greer, P.A. J. Leukoc. Biol. (2006) [Pubmed]
  11. Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Craig, A.W., Greer, P.A. Mol. Cell. Biol. (2002) [Pubmed]
  12. Insulin-like growth factor I receptor gene is concordant with c-Fes protooncogene and mouse chromosome 7 in somatic cell hybrids. Sundaresan, S., Francke, U. Somat. Cell Mol. Genet. (1989) [Pubmed]
  13. Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis. Zirngibl, R.A., Senis, Y., Greer, P.A. Mol. Cell. Biol. (2002) [Pubmed]
  14. Fes mediates the IL-4 activation of insulin receptor substrate-2 and cellular proliferation. Jiang, H., Foltenyi, K., Kashiwada, M., Donahue, L., Vuong, B., Hehn, B., Rothman, P. J. Immunol. (2001) [Pubmed]
  15. Glycosylated antitumor ether lipids are more effective against oncogene-transformed fibroblasts than alkyllysophospholipids. Samadder, P., Byun, H.S., Bittman, R., Arthur, G. Anticancer Res. (1998) [Pubmed]
  16. Anxiogenic treatments do not increase fear-potentiated startle in mice. Risbrough, V.B., Geyer, M.A. Biol. Psychiatry (2005) [Pubmed]
  17. Expression of two myeloid cell-specific genes requires the novel transcription factor, c-fes expression factor. Heydemann, A., Boehmler, J.H., Simon, M.C. J. Biol. Chem. (1997) [Pubmed]
  18. Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival. Sangrar, W., Gao, Y., Bates, B., Zirngibl, R., Greer, P.A. Exp. Hematol. (2004) [Pubmed]
  19. The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly. Laurent, C.E., Delfino, F.J., Cheng, H.Y., Smithgall, T.E. Mol. Cell. Biol. (2004) [Pubmed]
  20. The myeloid-cell-specific c-fes promoter is regulated by Sp1, PU.1, and a novel transcription factor. Heydemann, A., Juang, G., Hennessy, K., Parmacek, M.S., Simon, M.C. Mol. Cell. Biol. (1996) [Pubmed]
  21. Comparative genetics of albinism. Searle, A.G. Ophthalmic paediatrics and genetics. (1990) [Pubmed]
  22. Fps/Fes and Fer non-receptor protein-tyrosine kinases regulate collagen- and ADP-induced platelet aggregation. Senis, Y.A., Sangrar, W., Zirngibl, R.A., Craig, A.W., Lee, D.H., Greer, P.A. J. Thromb. Haemost. (2003) [Pubmed]
  23. Truncation of c-fes via gene targeting results in embryonic lethality and hyperproliferation of hematopoietic cells. Hackenmiller, R., Simon, M.C. Dev. Biol. (2002) [Pubmed]
  24. Genetic mapping of the mouse oncogenes c-Ha-ras-1 and c-fes to chromosome 7. Kozak, C.A., Sears, J.F., Hoggan, M.D. J. Virol. (1983) [Pubmed]
  25. Microsatellite instability in IVS3 of murine c-fes gene: tumor-associated rearrangement and mammalian divergence. Volpi, L., Beghini, A., Rossi, D., Larizza, L. Mamm. Genome (1996) [Pubmed]
  26. Expression of proto-oncogenes in xenografts of human renal cell carcinomas. Karthaus, H.F., Bussemakers, M.J., Schalken, J.A., Kurth, K.H., Feitz, W.F., Debruyne, F.M., Bloemers, H.P., Van de Ven, W.J. Urol. Res. (1987) [Pubmed]
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