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Sh3pxd2a  -  SH3 and PX domains 2A

Mus musculus

Synonyms: 2310014D11Rik, AA589508, AI256723, AI413738, C230050L11, ...
 
 
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Disease relevance of Sh3pxd2a

  • We used a phage display screen with the fifth SH3 domain of Fish and isolated ADAM19 as a binding partner [1].
  • CONCLUSION: Fish scales are able to induce an irritant dermatitis [2].
  • Collections of hematophagous Diptera at the Kingsbury State Fish and Wildlife Area in northern Indiana between 1982 and 1984 yielded 118,972 mosquitoes from which 5 isolates of Jamestown Canyon virus and 3 isolates of trivittatus virus were obtained [3].
  • Localization Effect on the Metal Biosorption Capability of Recombinant Mammalian and Fish Metallothioneins in Escherichia coli [4].
  • PROCEDURE: Fish were inoculated with mouse myeloma line cells P3.NS-1/1Ag4.1 (NS-1) or chicken Marek's disease tumor-derived lymphoma line cells (MDCC MSB-1) [5].
 

High impact information on Sh3pxd2a

  • Treatment of cells with cytochalasin D also resulted in rapid tyrosine phosphorylation of Fish, concomitant with activation of Src [6].
  • These data suggest that Fish is involved in signalling by tyrosine kinases, and imply a specialized role in the actin cytoskeleton [6].
  • In Src-transformed cells, ADAM12 co-localized with Fish in podosomes [1].
  • Because members of the ADAMs family have been implicated in growth factor processing, as well as cell adhesion and motility, Fish could be acting as an adaptor molecule that allows Src to impinge on these processes [1].
  • We have determined that the PX domain of Fish binds 3-phosphorylated phosphatidylinositols (including phosphatidylinositol 3-phosphate and phosphatidylinositol 3,4-bisphosphate) [1].
 

Chemical compound and disease context of Sh3pxd2a

  • RESULTS: Fish challenged with a large amount of scrapie mouse brain homogenate by either oral or parenteral routes, showed the ability to clear the majority of infectivity load [7].
 

Biological context of Sh3pxd2a

  • According to the diet, a significant difference was found in the Fish Oil, in which palate exhibited fewer AgNOR particles than that of the control group, both for BS and SBS (p < 0.05 and 0.152, respectively), indicating a reduced cell proliferation [8].
 

Anatomical context of Sh3pxd2a

  • Consistent with this, a fusion protein of green fluorescent protein and the Fish PX domain localized to punctate structures similar to endosomes in normal fibroblasts [1].
  • The surface marker labelled by this mab is expressed at relative low levels on the membrane of large, nearly nongranulated trout leucocytes, and having the typical morphology of monocytes in flow cytometry (Kfoury et al., 1999, Fish Pathology, 34, 1-6) [9].
 

Associations of Sh3pxd2a with chemical compounds

  • After weaning, BALB/c mice were assigned to four diets: Control (C), Corn Oil (CO), Fish (FO) and Olein (O) [8].

References

  1. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. Abram, C.L., Seals, D.F., Pass, I., Salinsky, D., Maurer, L., Roth, T.M., Courtneidge, S.A. J. Biol. Chem. (2003) [Pubmed]
  2. Fish scale-induced dermatitis. Chiou, F.Y., Tschen, J.A. J. Am. Acad. Dermatol. (1993) [Pubmed]
  3. Virus-vector-host relationships of Aedes stimulans and Jamestown Canyon virus in a northern Indiana enzootic focus. Boromisa, R.D., Grimstad, P.R. Am. J. Trop. Med. Hyg. (1986) [Pubmed]
  4. Localization Effect on the Metal Biosorption Capability of Recombinant Mammalian and Fish Metallothioneins in Escherichia coli. Kao, W.C., Chiu, Y.P., Chang, C.C., Chang, J.S. Biotechnol. Prog. (2006) [Pubmed]
  5. Induction of specific cytotoxic T-cell activity against xenogeneic target cells in carp (Cyprinus carpio). Yamamoto, K., Mukamoto, M., Watarai, S., Kodama, H., Nakayasu, C., Okamoto, N. Am. J. Vet. Res. (2001) [Pubmed]
  6. A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate. Lock, P., Abram, C.L., Gibson, T., Courtneidge, S.A. EMBO J. (1998) [Pubmed]
  7. Scrapie infectivity is quickly cleared in tissues of orally-infected farmed fish. Ingrosso, L., Novoa, B., Valle, A.Z., Cardone, F., Aranguren, R., Sbriccoli, M., Bevivino, S., Iriti, M., Liu, Q., Vetrugno, V., Lu, M., Faoro, F., Ciappellano, S., Figueras, A., Pocchiari, M. BMC Vet. Res. (2006) [Pubmed]
  8. Effects of dietary lipids on cell proliferation of murine oral mucosa. Actis, A.B., Joekes, S., Cremonezzi, D., Morales, G., Eynard, A.R. Lipids in health and disease [electronic resource]. (2002) [Pubmed]
  9. A monoclonal antibody recognising a surface marker on rainbow trout (Oncorhynchus mykiss) monocytes. Köllner, B., Blohm, U., Kotterba, G., Fischer, U. Fish Shellfish Immunol. (2001) [Pubmed]
 
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