The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Ncs1  -  neuronal calcium sensor 1

Mus musculus

Synonyms: 9430075O15Rik, A730032G13Rik, AI836659, Freq, Frequenin homolog, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Freq

 

Psychiatry related information on Freq

  • To determine whether InsP3R1/NCS-1 interaction could be functionally relevant in bipolar disorders, conditions in which NCS-1 is highly expressed, we tested the effect of lithium, a salt widely used for treatment of bipolar disorders [2].
 

High impact information on Freq

 

Biological context of Freq

  • Like calmodulin, NCS-1 is a member of a family of calcium binding proteins that contain EF-hand motifs, which bind calcium and induce conformational changes in the protein [5].
  • These results showed the diverse localization of NCS-1 in pre- and/or postsynaptic elements of the hippocampus and cerebellum, and suggest potential roles in specific synaptic transmission [6].
  • The amino acid sequence of Mfreq is homologous to that of frequenins from other species [7].
  • The number of action potentials that elicited endplate potentials increased in NG108-15 cells stably transformed with rat NCS-1 [1].
 

Anatomical context of Freq

 

Associations of Freq with chemical compounds

  • The effect of NCS-1 was specific for GLUT4 and the insulin-responsive aminopeptidase translocation as there was no effect on the trafficking of the cation-independent mannose 6-phosphate receptor or the GLUT1 glucose transporter isoform [9].
  • The inhibitory action of NCS-1 was independent of calcium sequestration since neither treatment with ionomycin nor endothelin-1, both of which elevated the intracellular calcium concentration, restored insulin-stimulated GLUT4 translocation [9].
  • These results show that NCS-1 functions to facilitate synapse formation, probably because of the increased quantal content of evoked acetylcholine release [1].
  • In coronal sections, the NCS-1 immunostaining displayed characteristic parasagittal banding pattern in the Purkinje cell layer and molecular layer, while there were no apparent bands in the granule cell layer [10].
  • Calcium, guanosine 5'-O-(3'-thiotriphosphate) (GTP-gamma-S) and mastoparan stimulated ACTH secretion from permeabilised wild type AtT-20 and NCS-1 over-expressing AtT-20 cells with significantly greater ACTH secretion obtained in NCS-1 over-expressing cells [11].
 

Co-localisations of Freq

  • Endogenous NCS-1 was partially co-localized with the synaptic protein SNAP-25 at the plasma membrane in both cell bodies and processes, but not with the Golgi marker [beta]-COP, an individual coat subunit of the coatomer complex present on Golgi-derived vesicles [1].
 

Other interactions of Freq

 

Analytical, diagnostic and therapeutic context of Freq

References

  1. Overexpression of rat neuronal calcium sensor-1 in rodent NG108-15 cells enhances synapse formation and transmission. Chen, X.L., Zhong, Z.G., Yokoyama, S., Bark, C., Meister, B., Berggren, P.O., Roder, J., Higashida, H., Jeromin, A. J. Physiol. (Lond.) (2001) [Pubmed]
  2. Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium. Schlecker, C., Boehmerle, W., Jeromin, A., DeGray, B., Varshney, A., Sharma, Y., Szigeti-Buck, K., Ehrlich, B.E. J. Clin. Invest. (2006) [Pubmed]
  3. Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta. Gromada, J., Bark, C., Smidt, K., Efanov, A.M., Janson, J., Mandic, S.A., Webb, D.L., Zhang, W., Meister, B., Jeromin, A., Berggren, P.O. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Modulation of Kv4-encoded K(+) currents in the mammalian myocardium by neuronal calcium sensor-1. Guo, W., Malin, S.A., Johns, D.C., Jeromin, A., Nerbonne, J.M. J. Biol. Chem. (2002) [Pubmed]
  5. Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway. Treloar, H.B., Uboha, U., Jeromin, A., Greer, C.A. J. Comp. Neurol. (2005) [Pubmed]
  6. Immunocytochemical localization of neuronal calcium sensor-1 in the hippocampus and cerebellum of the mouse, with special reference to presynaptic terminals. Jinno, S., Jeromin, A., Roder, J., Kosaka, T. Neuroscience (2002) [Pubmed]
  7. The Ca2+ binding protein, frequenin is a nervous system-specific protein in mouse preferentially localized in neurites. Olafsson, P., Soares, H.D., Herzog, K.H., Wang, T., Morgan, J.I., Lu, B. Brain Res. Mol. Brain Res. (1997) [Pubmed]
  8. Developmental expression of NCS-1 (frequenin), a regulator of Kv4 K+ channels, in mouse heart. Nakamura, T.Y., Sturm, E., Pountney, D.J., Orenzoff, B., Artman, M., Coetzee, W.A. Pediatr. Res. (2003) [Pubmed]
  9. NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway. Mora, S., Durham, P.L., Smith, J.R., Russo, A.F., Jeromin, A., Pessin, J.E. J. Biol. Chem. (2002) [Pubmed]
  10. Compartmentation of the mouse cerebellar cortex by neuronal calcium sensor-1. Jinno, S., Jeromin, A., Roder, J., Kosaka, T. J. Comp. Neurol. (2003) [Pubmed]
  11. Over-expression of NCS-1 in AtT-20 cells affects ACTH secretion and storage. Guild, S.B., Murray, A.T., Wilson, M.L., Wiegand, U.K., Apps, D.K., Jin, Y., Rindler, M., Roder, J., Jeromin, A. Mol. Cell. Endocrinol. (2001) [Pubmed]
 
WikiGenes - Universities