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Gene Review

qacEdelta1  -  hypothetical protein

Escherichia coli

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Disease relevance of qacEdelta1


High impact information on qacEdelta1

  • We have cloned the plasmid-quinolone resistance gene, termed qnr, and found it in an integron-like environment upstream from qacE Delta 1 and sulI [3].
  • Sixty-three percent of the clinical isolates were positive for the class 1 integron markers intI1 and qacEDelta1 [1].
  • Transfer of antimicrobial resistance (ampicillin, streptomycin and sulphonamides), the tem-1 gene and markers (int1, qacEDelta1, sul1) characteristic of class 1 integrons were evident in one MDR isolate (resistant to 4 antimicrobial classes) when conjugation and transformation experiments were performed [4].
  • The nucleotide sequences of qacE delta 1 genes isolated from environmental isolates of V. cholerae non-O1 and V. parahaemolyticus differed by one base from that of the gene from P. aeruginosa [2].

Biological context of qacEdelta1


  1. Incidence and characterization of integrons, genetic elements mediating multiple-drug resistance, in avian Escherichia coli. Bass, L., Liebert, C.A., Lee, M.D., Summers, A.O., White, D.G., Thayer, S.G., Maurer, J.J. Antimicrob. Agents Chemother. (1999) [Pubmed]
  2. Characterization of the antiseptic-resistance gene qacE delta 1 isolated from clinical and environmental isolates of Vibrio parahaemolyticus and Vibrio cholerae non-O1. Kazama, H., Hamashima, H., Sasatsu, M., Arai, T. FEMS Microbiol. Lett. (1999) [Pubmed]
  3. Mechanism of plasmid-mediated quinolone resistance. Tran, J.H., Jacoby, G.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Antimicrobial resistance in Irish isolates of verocytotoxigenic Escherichia coli (E. coli)--VTEC. Walsh, C., Duffy, G., O'Mahony, R., Fanning, S., Blair, I.S., McDowell, D.A. Int. J. Food Microbiol. (2006) [Pubmed]
  5. Plasmid pDGO100 contains a second integron with the trimethoprim resistance gene dfrA7 as the inserted cassette. Burnside, J.M., Groot Obbink, D.J. Plasmid (1996) [Pubmed]
  6. DNA fingerprinting of Salmonella enterica subsp. enterica serovar typhimurium with emphasis on phage type DT104 based on variable number of tandem repeat loci. Lindstedt, B.A., Heir, E., Gjernes, E., Kapperud, G. J. Clin. Microbiol. (2003) [Pubmed]
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