Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

strA - hypothetical protein

Salmonella typhimurium

Pezzella, C. et al., Peirano, G. et al., Michael, G.B. et al., Madsen, L. et al.

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Disease relevance of strA

The strA and strB genes were highly prevalent in Salmonella strains of our collection, being detected in 84% of the streptomycin-resistant strains [1].
In many strains, the strA and strB genes were linked to a particular Tn5393-derivative transposon characterized by the presence of the insertion sequence IS1133, previously identified only in the plant pathogen Erwinia amylovora [1].

High impact information on strA

Fifty-eight multidrug-resistant Salmonella enterica strains of 20 serotypes, isolated from animal sources in Italy, were analyzed for tet(A) and strA-strB, conferring tetracycline and streptomycin resistance, respectively [1].
Sulphonamide resistance was primarily mediated by sul2 and sul3, tetracycline resistance by tet(B) and tet(A), chloramphenicol resistance by catA1, streptomycin resistance by strA and ampicillin resistance by blaTEM. blaCTX and blaCMY-2 were found in cephalosporin-resistant isolates [2].
In addition, it harboured a streptomycin resistance gene strA and a class 1 integron with a new aadA variant designated aadA23, which mediates resistance to streptomycin and spectinomycin [3].

Other interactions of strA

Partial sequences were obtained of strA and strB in seven strains [4].

References

Tetracycline and streptomycin resistance genes, transposons, and plasmids in Salmonella enterica isolates from animals in Italy. Pezzella, C., Ricci, A., DiGiannatale, E., Luzzi, I., Carattoli, A. Antimicrob. Agents Chemother. (2004) [Pubmed]
Occurrence of integrons and antimicrobial resistance genes among Salmonella enterica from Brazil. Peirano, G., Agersø, Y., Aarestrup, F.M., dos Reis, E.M., dos Prazeres Rodrigues, D. J. Antimicrob. Chemother. (2006) [Pubmed]
Class 1 integron-associated gene cassettes in Salmonella enterica subsp. enterica serovar Agona isolated from pig carcasses in Brazil. Michael, G.B., Cardoso, M., Schwarz, S. J. Antimicrob. Chemother. (2005) [Pubmed]
Characterisation of streptomycin resistance determinants in Danish isolates of Salmonella Typhimurium. Madsen, L., Aarestrup, F.M., Olsen, J.E. Vet. Microbiol. (2000) [Pubmed]

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