Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

yopD - translocator YopD

Yersinia enterocolitica

Hartland, E.L. et al., Sarker, M.R. et al., Anderson, D.M. et al., Francis, M.S. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on yopD

This yopD null mutant (YPIII/pIB621) was also non-cytotoxic towards HeLa cell monolayers, supporting the role for YopD in the translocation process [1].
This property of the bacterium was abrogated by curing the strain of its 71.5-kb virulence plasmid and by transposon mutagenesis of the plasmid-borne yopD gene [2].
Derivatives of the bacterium which were unable to inhibit the respiratory burst were also less able to disrupt cytoskeletal actin and to resist phagocytosis. yopD mutants also showed an impaired ability to dephosphorylate phosphotyrosine residues in macrophage proteins and were completely avirulent for mice [2].
Experiments with transcriptional and translational fusions to the npt reporter gene suggest that yopD and lcrH regulate yopQ expression at a posttranscriptional step [3].
Complementation experiments showed that the mutation was not polar with regard to yopB and yopD [4].

Analytical, diagnostic and therapeutic context of yopD

Northern blot analysis showed that transcription of yopD was not affected [4].

References

YopD of Yersinia pseudotuberculosis is translocated into the cytosol of HeLa epithelial cells: evidence of a structural domain necessary for translocation. Francis, M.S., Wolf-Watz, H. Mol. Microbiol. (1998) [Pubmed]
Essential role of YopD in inhibition of the respiratory burst of macrophages by Yersinia enterocolitica. Hartland, E.L., Green, S.P., Phillips, W.A., Robins-Browne, R.M. Infect. Immun. (1994) [Pubmed]
YopD and LcrH regulate expression of Yersinia enterocolitica YopQ by a posttranscriptional mechanism and bind to yopQ RNA. Anderson, D.M., Ramamurthi, K.S., Tam, C., Schneewind, O. J. Bacteriol. (2002) [Pubmed]
The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD. Sarker, M.R., Neyt, C., Stainier, I., Cornelis, G.R. J. Bacteriol. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.