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Gene Review:

lcrD - required for Yop secretion

Yersinia enterocolitica

Andrews, G.P. et al., Ginocchio, C.C. et al.

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Disease relevance of lcrD

While a homology search did not reveal any significant relatedness of the mxiA DNA sequence to any known bacterial gene sequences, the derived amino acid sequence of MxiA was found to be highly homologous (68%) to the sequence of the protein encoded by the low-calcium-response locus, lcrD, of Yersinia pestis [1].
However, a plasmid carrying a gene encoding a chimeric protein consisting of the amino terminus of LcrD and the carboxy terminus of InvA complemented the defect of the Salmonella invA mutant [2].

References

mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid antigens, encodes a homolog of the low-calcium-response protein, LcrD, of Yersinia pestis. Andrews, G.P., Maurelli, A.T. Infect. Immun. (1992) [Pubmed]
Functional conservation among members of the Salmonella typhimurium InvA family of proteins. Ginocchio, C.C., Galán, J.E. Infect. Immun. (1995) [Pubmed]

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