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Gene Review

tetL  -  confers tetracycline resistance

Enterococcus faecalis

 
 
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Disease relevance of tetL

  • Characterization and heterologous expression of the tetL gene and identification of iso-ISS1 elements from Enterococcus faecalis plasmid pJH1 [1].
  • Upstream of the pJH1 tetL, part of another ORF was found that, except for two single-nt substitutions, was identical to an iso-ISS1 element from Lactococcus lactis [1].
  • To study its usefulness as a marker in Gram+ organisms, the pJH1 tetL was cloned on the broad-host-range plasmid pNZ124, resulting in pNZ280, that was found to give resistance to 40 micrograms Tc/ml in Lc. lactis and Bacillus subtilis [1].
  • The nt sequence of tetL from pJH1 was identical to that of the tetL present on pLS1 from Streptococcus agalactiae [1].
  • No sequence homology was detected in any strain with probes corresponding to the tetL gene of group B Streptococcus origin, to the ermA gene of the transposon Tn554 of Staphylococcus aureus origin, or to the cat genes of either pC194 or pC221 of S. aureus origin [2].
 

High impact information on tetL

 

Associations of tetL with chemical compounds

  • Energy-dependent efflux mediated by class L (tetL) tetracycline resistance determinant from streptococci [6].
 

Analytical, diagnostic and therapeutic context of tetL

  • One RAPD PCR produced an identical pattern for 18 transconjugants and the recipient and a clearly different pattern for the remaining 6 transconjugants due to a newly appearing fragment resulting from acquisition of the tetL gene [7].

References

  1. Characterization and heterologous expression of the tetL gene and identification of iso-ISS1 elements from Enterococcus faecalis plasmid pJH1. Platteeuw, C., Michiels, F., Joos, H., Seurinck, J., de Vos, W.M. Gene (1995) [Pubmed]
  2. Genetic basis of antibiotic resistance in Aerococcus viridans. Buu-Hoï, A., Le Bouguénec, C., Horaud, T. Antimicrob. Agents Chemother. (1989) [Pubmed]
  3. Occurrence of the Campylobacter resistance gene tetO in Enterococcus and Streptococcus spp. Zilhao, R., Papadopoulou, B., Courvalin, P. Antimicrob. Agents Chemother. (1988) [Pubmed]
  4. Location of antibiotic resistance markers in clinical isolates of Enterococcus faecalis with similar antibiotypes. Pepper, K., Horaud, T., Le Bouguénec, C., de Cespédès, G. Antimicrob. Agents Chemother. (1987) [Pubmed]
  5. Effects of orally administered tetracycline on the intestinal community structure of chickens and on tet determinant carriage by commensal bacteria and Campylobacter jejuni. Fairchild, A.S., Smith, J.L., Idris, U., Lu, J., Sanchez, S., Purvis, L.B., Hofacre, C., Lee, M.D. Appl. Environ. Microbiol. (2005) [Pubmed]
  6. Energy-dependent efflux mediated by class L (tetL) tetracycline resistance determinant from streptococci. McMurry, L.M., Park, B.H., Burdett, V., Levy, S.B. Antimicrob. Agents Chemother. (1987) [Pubmed]
  7. Influence of transferable genetic determinants on the outcome of typing methods commonly used for Enterococcus faecium. Werner, G., Willems, R.J., Hildebrandt, B., Klare, I., Witte, W. J. Clin. Microbiol. (2003) [Pubmed]
 
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