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Gene Review:

abiK - AbiK

Lactococcus lactis

Fortier, L.C. et al., Boucher, I. et al., Emond, E. et al., Bouchard, J.D. et al., Bouchard, J.D. et al.

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Disease relevance of abiK

These data suggest that an RT activity might be involved in the phage resistance activity of AbiK [1].
Phenotypic and genetic characterization of the bacteriophage abortive infection mechanism AbiK from Lactococcus lactis [2].

High impact information on abiK

The abiK gene was shown to be part of an operon that includes two additional open reading frames, with one of these encoding a phage-related transcriptional repressor named Orf4 [1].
Here, we report the analysis of the second class of phage mutants, which are insensitive to AbiK as a result of a single nucleotide change causing an amino acid substitution [3].
Both mutants generated by these recombination events are insensitive to the phage resistance mechanism AbiK and one has a reduced burst size as well as a new origin of replication [4].
No phage DNA replication nor phage structural protein production was detected in infected AbiK+ L. lactis cells [2].
The genes involved in the phage resistance systems LlaDCHI, AbiK, and AbiQ were found in close proximity to and downstream of the replication modules [5].

Biological context of abiK

The three Lactococcus lactis plasmids pSRQ700, pSRQ800, and pSRQ900 encode the previously described anti-phage resistance mechanisms LlaDCHI, AbiK, and AbiQ, respectively [5].

Analytical, diagnostic and therapeutic context of abiK

The N-terminal half of the deduced AbiK protein possesses an RT motif that was modified by site-directed mutagenesis [1].

References

Expression and site-directed mutagenesis of the lactococcal abortive phage infection protein AbiK. Fortier, L.C., Bouchard, J.D., Moineau, S. J. Bacteriol. (2005) [Pubmed]
Phenotypic and genetic characterization of the bacteriophage abortive infection mechanism AbiK from Lactococcus lactis. Emond, E., Holler, B.J., Boucher, I., Vandenbergh, P.A., Vedamuthu, E.R., Kondo, J.K., Moineau, S. Appl. Environ. Microbiol. (1997) [Pubmed]
Lactococcal phage genes involved in sensitivity to AbiK and their relation to single-strand annealing proteins. Bouchard, J.D., Moineau, S. J. Bacteriol. (2004) [Pubmed]
Homologous recombination between a lactococcal bacteriophage and the chromosome of its host strain. Bouchard, J.D., Moineau, S. Virology (2000) [Pubmed]
DNA sequence analysis of three Lactococcus lactis plasmids encoding phage resistance mechanisms. Boucher, I., Emond, E., Parrot, M., Moineau, S. J. Dairy Sci. (2001) [Pubmed]

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