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Gene Review:

SSO2720 - aminotransferase

Sulfolobus solfataricus P2

Palmieri, G. et al., Tanaka, T. et al.

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Disease relevance of SSO2720

On the other hand, the Methanobacterium AspAT showed remarkable amino acid sequence homology, 31.5%, with rat serine:pyruvate aminotransferase and, 13.5%, with E. coli phosphoserine aminotransferase [1].

High impact information on SSO2720

3-Amino-2,3-dihydrobenzoic acid is an inhibitor of the aminotransferase activity [2].
The absorption spectrum of the purified aminotransferase is indicative of the presence of pyridoxamine 5'-phosphate (PMP) cofactor, and the catalytic activity of the enzyme is further stimulated by addition of PMP [2].

References

Aspartate aminotransferase from a thermophilic formate-utilizing methanogen, Methanobacterium thermoformicicum strain SF-4: relation to serine and phosphoserine aminotransferases, but not to the aspartate aminotransferase family. Tanaka, T., Yamamoto, S., Moriya, T., Taniguchi, M., Hayashi, H., Kagamiyama, H., Oi, S. J. Biochem. (1994) [Pubmed]
Glutamate-1-semialdehyde aminotransferase from Sulfolobus solfataricus. Palmieri, G., Di Palo, M., Scaloni, A., Orru, S., Marino, G., Sannia, G. Biochem. J. (1996) [Pubmed]

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