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Gene Review

Gcnt2  -  glucosaminyl (N-acetyl) transferase 2, I...

Mus musculus

Synonyms: 5330430K10Rik, I-branching enzyme, IGNT, IGnT, IGnTA, ...
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Disease relevance of Gcnt2


High impact information on Gcnt2


Biological context of Gcnt2


Anatomical context of Gcnt2


Associations of Gcnt2 with chemical compounds


Regulatory relationships of Gcnt2


Other interactions of Gcnt2


Analytical, diagnostic and therapeutic context of Gcnt2

  • IGnT protein was detected by immunohistochemistry using the IGnT fusion-protein antibody [1].
  • Northern blot analysis of beta-1, 4-GalTs I, II, III, IV, V, and VI and N-acetylglucosaminyltransferase (GlcNAcT)V in human cancer cell lines showed that the gene expression levels of beta-1,4-GalT V but not other beta-1,4-GalTs are strongly correlated with those of GlcNAcT V whose activity was shown to increase by malignant transformation [27].
  • Changes in the enzymatic activities of other glycosyltransferases, such as alpha1,3-galactosyltransferase, and alpha-6-D-mannoside beta-1,6 N-acetylglucosaminyltransferase V, did not point to any interaction between GnT-III and these enzymes in the transgenic mice, suggesting that this approach may be useful in clinical xenotransplantation [28].


  1. Expression of the large I antigen forming beta-1,6-N-acetylglucosaminyltransferase in various tissues of adult mice. Magnet, A.D., Fukuda, M. Glycobiology (1997) [Pubmed]
  2. A novel variant form of murine beta-1, 6-N-acetylglucosaminyltransferase forming branches in poly-N-acetyllactosamines. Chen, G.Y., Kurosawa, N., Muramatsu, T. Glycobiology (2000) [Pubmed]
  3. Transforming growth factor beta up-regulates expression of the N-acetylglucosaminyltransferase V gene in mouse melanoma cells. Miyoshi, E., Nishikawa, A., Ihara, Y., Saito, H., Uozumi, N., Hayashi, N., Fusamoto, H., Kamada, T., Taniguchi, N. J. Biol. Chem. (1995) [Pubmed]
  4. Aberrant glycosylation of E-cadherin enhances cell-cell binding to suppress metastasis. Yoshimura, M., Ihara, Y., Matsuzawa, Y., Taniguchi, N. J. Biol. Chem. (1996) [Pubmed]
  5. A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc: alpha-D-mannoside beta 1,6 N-acetylglucosaminyltransferase. Cummings, R.D., Trowbridge, I.S., Kornfeld, S. J. Biol. Chem. (1982) [Pubmed]
  6. Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V. Demetriou, M., Nabi, I.R., Coppolino, M., Dedhar, S., Dennis, J.W. J. Cell Biol. (1995) [Pubmed]
  7. Essential role for complex N-glycans in forming an organized layer of bronchial epithelium. Ioffe, E., Liu, Y., Stanley, P. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  8. The monoclonal antibody CHO-131 binds to a core 2 O-glycan terminated with sialyl-Lewis x, which is a functional glycan ligand for P-selectin. Walcheck, B., Leppanen, A., Cummings, R.D., Knibbs, R.N., Stoolman, L.M., Alexander, S.R., Mattila, P.E., McEver, R.P. Blood (2002) [Pubmed]
  9. Bisecting N-acetylglucosamine on K562 cells suppresses natural killer cytotoxicity and promotes spleen colonization. Yoshimura, M., Ihara, Y., Ohnishi, A., Ijuhin, N., Nishiura, T., Kanakura, Y., Matsuzawa, Y., Taniguchi, N. Cancer Res. (1996) [Pubmed]
  10. Mouse large can modify complex N- and mucin O-glycans on alpha-dystroglycan to induce laminin binding. Patnaik, S.K., Stanley, P. J. Biol. Chem. (2005) [Pubmed]
  11. Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity. Yen, T.Y., Macher, B.A., Bryson, S., Chang, X., Tvaroska, I., Tse, R., Takeshita, S., Lew, A.M., Datti, A. J. Biol. Chem. (2003) [Pubmed]
  12. The molecular genetics of the mouse I beta-1,6-N-acetylglucosaminyltransferase locus. Twu, Y.C., Chou, M.L., Yu, L.C. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  13. Minimal catalytic domain of N-acetylglucosaminyltransferase V. Korczak, B., Le, T., Elowe, S., Datti, A., Dennis, J.W. Glycobiology (2000) [Pubmed]
  14. Differential requirements for core2 glucosaminyltransferase for endothelial L-selectin ligand function in vivo. Sperandio, M., Forlow, S.B., Thatte, J., Ellies, L.G., Marth, J.D., Ley, K. J. Immunol. (2001) [Pubmed]
  15. N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells. Morgan, R., Gao, G., Pawling, J., Dennis, J.W., Demetriou, M., Li, B. J. Immunol. (2004) [Pubmed]
  16. Modification of CD43 and other lymphocyte O-glycoproteins by core 2 N-acetylglucosaminyltransferase. Barran, P., Fellinger, W., Warren, C.E., Dennis, J.W., Ziltener, H.J. Glycobiology (1997) [Pubmed]
  17. Activity of UDP-GlcNAc:alpha-mannoside beta(1,6)N-acetylglucosaminyltransferase (GnT V) in cultured cells using a synthetic trisaccharide acceptor. Pierce, M., Arango, J., Tahir, S.H., Hindsgaul, O. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  18. Preparation of antisera to recombinant, soluble N-acetylglucosaminyltransferase V and its visualization in situ. Chen, L., Zhang, N., Adler, B., Browne, J., Freigen, N., Pierce, M. Glycoconj. J. (1995) [Pubmed]
  19. Enzymatic addition of O-GlcNAc to nuclear and cytoplasmic proteins. Identification of a uridine diphospho-N-acetylglucosamine:peptide beta-N-acetylglucosaminyltransferase. Haltiwanger, R.S., Holt, G.D., Hart, G.W. J. Biol. Chem. (1990) [Pubmed]
  20. Deletion of mouse embryo fibroblast N-acetylglucosaminyltransferase V stimulates alpha5beta1 integrin expression mediated by the protein kinase C signaling pathway. Guo, H.B., Lee, I., Bryan, B.T., Pierce, M. J. Biol. Chem. (2005) [Pubmed]
  21. The her-2/neu oncogene stimulates the transcription of N-acetylglucosaminyltransferase V and expression of its cell surface oligosaccharide products. Chen, L., Zhang, W., Fregien, N., Pierce, M. Oncogene (1998) [Pubmed]
  22. GlcNAc-transferase V and core 2 GlcNAc-transferase expression in the developing mouse embryo. Granovsky, M., Fode, C., Warren, C.E., Campbell, R.M., Marth, J.D., Pierce, M., Fregien, N., Dennis, J.W. Glycobiology (1995) [Pubmed]
  23. Regulation of N-linked glycosylation. Neuronal cell-specific expression of a 5' extended transcript from the gene encoding N-acetylglucosaminyltransferase I. Yang, J., Bhaumik, M., Liu, Y., Stanley, P. Glycobiology (1994) [Pubmed]
  24. Lipopolysaccharide Induces Mucus Cell Metaplasia in Mouse Lung. Yanagihara, K., Seki, M., Cheng, P.W. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  25. Uvomorulin, LAMP-1, and laminin are substrates for cell surface beta-1,4-galactosyltransferase on F9 embryonal carcinoma cells: comparisons between wild-type and mutant 5.51 att- cells. Maillet, C.M., Shur, B.D. Exp. Cell Res. (1993) [Pubmed]
  26. Restricted replication of two alphaviruses in ricin-resistant mouse L cells with altered glycosyltransferase activities. Gottlieb, C., Kornfeld, S., Schlesinger, S. J. Virol. (1979) [Pubmed]
  27. Correlated gene expression between beta-1,4-galactosyltransferase V and N-acetylglucosaminyltransferase V in human cancer cell lines. Sato, T., Shirane, K., Kido, M., Furukawa, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  28. Remodeling of the major mouse xenoantigen, Galalpha1-3Galbeta1-4GlcNAc-R, by N-acetylglucosaminyltransferase-III. Chung, T.W., Kim, K.S., Kang, S.K., Lee, J.W., Song, E.Y., Chung, T.H., Yeom, Y.I., Kim, C.H. Mol. Cells (2003) [Pubmed]
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