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Gpr3  -  G-protein coupled receptor 3

Mus musculus

Synonyms: GPCR21, Gpcr20, Gpcr21, Gpcr3
 
 
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Disease relevance of Gpr3

 

High impact information on Gpr3

  • To determine whether GPR3 activates G(s), the localization of Galpha(s) in follicle-enclosed oocytes from Gpr3(+/+) and Gpr3(-/-) mice was compared by using immunofluorescence and Galpha(s)GFP [2].
  • Detailed analysis of the phenotype confirms premature resumption of meiosis, in vivo, in about one-third of antral follicles from Gpr3-/- females, independently of their age [1].
  • Here we show that mice deficient for Gpr3 are unexpectedly fertile but display progressive reduction in litter size despite stable age-independent alteration of meiotic pause [1].
  • To investigate whether Gpr3 in the follicle cells contributes to the maintenance of meiotic arrest, RNA interference (RNAi) was used to reduce the amount of Gpr3 RNA within follicle-enclosed oocytes [3].
  • Oocytes from Gpr3 knockout mice resume meiosis within antral follicles, independently of an increase in luteinizing hormone, and this phenotype can be reversed by injection of Gpr3 RNA into the oocytes [4].
 

Analytical, diagnostic and therapeutic context of Gpr3

  • Reduction of RNA was specific for Gpr3 because an unrelated gene was not reduced by microinjection of siRNA [3].

References

  1. Premature ovarian aging in mice deficient for Gpr3. Ledent, C., Demeestere, I., Blum, D., Petermans, J., Hämäläinen, T., Smits, G., Vassart, G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein. Freudzon, L., Norris, R.P., Hand, A.R., Tanaka, S., Saeki, Y., Jones, T.L., Rasenick, M.M., Berlot, C.H., Mehlmann, L.M., Jaffe, L.A. J. Cell Biol. (2005) [Pubmed]
  3. Oocyte-specific expression of Gpr3 is required for the maintenance of meiotic arrest in mouse oocytes. Mehlmann, L.M. Dev. Biol. (2005) [Pubmed]
  4. The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Mehlmann, L.M., Saeki, Y., Tanaka, S., Brennan, T.J., Evsikov, A.V., Pendola, F.L., Knowles, B.B., Eppig, J.J., Jaffe, L.A. Science (2004) [Pubmed]
 
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