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Gene Review:

grpE - heat shock protein GrpE

Methanosarcina mazei Go1

Conway de Macario, E. et al., Thomsen, J. et al., Conway De Macario, E. et al.

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Disease relevance of grpE

Transcription of the heat shock gene grpE was studied in two different morphologic stages of the archaeon Methanosarcina mazei S-6 that differ in resistance to physical and chemical traumas: single cells and packets [1].
This, and sequence homologies, suggest that the M. tuberculosis GrpE belongs, together with the Streptomyces coelicolor homolog, to a subgroup of the GrpE proteins [2].

High impact information on grpE

The CD spectra changed upon binding to the promoters of the stress genes grpE, dnaK, and dnaJ, with the changes being distinctive for each promoter; in contrast, no effect was produced by the promoter of a non-stress-gene [3].
The deduced amino acid sequence shows 28.2 to 34.6% identities, and 50.3 to 58.9 similarities (identities plus conservative substitutions) with the other six complete GrpE sequences available [2].

References

Archaeal grpE: transcription in two different morphologic stages of Methanosarcina mazei and comparison with dnaK and dnaJ. Conway De Macario, E., Clarens, M., Macario, A.J. J. Bacteriol. (1995) [Pubmed]
Identification of a grpE heat-shock gene homolog in the archaeon Methanosarcina mazei. Conway de Macario, E., Dugan, C.B., Macario, A.J. J. Mol. Biol. (1994) [Pubmed]
The basal transcription factors TBP and TFB from the mesophilic archaeon Methanosarcina mazeii: structure and conformational changes upon interaction with stress-gene promoters. Thomsen, J., De Biase, A., Kaczanowski, S., Macario, A.J., Thomm, M., Zielenkiewicz, P., MacColl, R., Conway de Macario, E. J. Mol. Biol. (2001) [Pubmed]

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