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Grik5  -  glutamate receptor, ionotropic, kainate 5...

Mus musculus

Synonyms: GluK5, GluR gamma-2, GluRgamma2, Glutamate receptor KA-2, Glutamate receptor gamma-2, ...
 
 
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High impact information on Grik5

  • The white matter showed consistent immunoreactivity for AMPA receptor subunit GluR2/3 and KA receptor subunits GluR6/7 and KA2 [1].
  • Both exclusively and abundantly, KA2 labeled oligodendrocytes and myelin, identified by CNPase expression [1].
  • The proximity of oligodendrocytic KA2 to the axonal node and the paucity of axonal AMPA/kainate receptor expression suggest that excitotoxic axonal damage may be secondary and, possibly, mediated by oligodendrocytes [1].
  • In addition, there was no significant difference in the levels of glutamate receptor subunits GluR1-4 or KA2 in Plp knockout compared with wild-type littermates [2].
  • In an attempt to gain knowledge of the possible functions of kainate receptors, we have used in situ hybridization to examine the regional and cellular expression patterns of glutamate receptor subunits GluR5-7, KA1 and KA2 in the adult mouse basal ganglia, known to play a pivotal role in the translation of motivation into actions [3].
 

Anatomical context of Grik5

 

Regulatory relationships of Grik5

  • KA2 was usually coexpressed with GluR6, although with a generally lower level of expression [3].
 

Analytical, diagnostic and therapeutic context of Grik5

  • Immunolabeling and Western blot analysis of kainate receptors using antibodies against the GluR6 and KA2 subunits, demonstrated that the immature cortical neurons used in this study express kainate receptor proteins [7].

References

  1. AMPA/kainate receptors in mouse spinal cord cell-specific display of receptor subunits by oligodendrocytes and astrocytes and at the nodes of Ranvier. Brand-Schieber, E., Werner, P. Glia (2003) [Pubmed]
  2. Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. Fowler, J.H., Edgar, J.M., Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I.R., Garbern, J.Y., Nave, K.A., Dewar, D. J. Neurosci. Res. (2006) [Pubmed]
  3. Spatial distribution of kainate receptor subunit mRNA in the mouse basal ganglia and ventral mesencephalon. Bischoff, S., Barhanin, J., Bettler, B., Mulle, C., Heinemann, S. J. Comp. Neurol. (1997) [Pubmed]
  4. Localization of kainate receptors at the cone pedicles of the primate retina. Haverkamp, S., Grünert, U., Wässle, H. J. Comp. Neurol. (2001) [Pubmed]
  5. Expression profiling of genes encoding glutamate and GABA receptor subunits in three immortalized GnRH cell lines. Garyfallou, V.T., Lemos, D., Urbanski, H.F. Brain Res. (2006) [Pubmed]
  6. Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2. Nasu-Nishimura, Y., Hurtado, D., Braud, S., Tang, T.T., Isaac, J.T., Roche, K.W. J. Neurosci. (2006) [Pubmed]
  7. Glutamate receptor agonist kainate enhances primary dendrite number and length from immature mouse cortical neurons in vitro. Monnerie, H., Le Roux, P.D. J. Neurosci. Res. (2006) [Pubmed]
 
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