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ZNF569  -  zinc finger protein 569

Homo sapiens

Synonyms: FLJ32053, ZAP1, ZNF, Zinc finger protein 569
 
 
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High impact information on ZNF569

  • The transcriptional activator Zap1 induces target gene expression in response to zinc deficiency [1].
  • High-resolution mapping on human chromosome 19 revealed that CBX1 coats large domains 0.1-4 Mb in size, which coincide with the position of KRAB-ZNF gene clusters [2].
  • The role of this regulation by Zap1p in limiting oxidative stress in low zinc was confirmed when the Zap1p-binding site was specifically mutated in the chromosomal TSA1 promoter [3].
  • One finger pair domain in Zap1 contains the AD2 transactivation domain [4].
  • The DNA binding activity of ZAP-1 first appears in oocytes from 19-day-old mouse embryos and reaches a maximum level at 10 days after birth [5].
 

Biological context of ZNF569

  • Here we report the identification and characterization of a novel KRAB-containing zinc-finger protein, ZNF569, which is isolated from a human embryonic heart cDNA library [6].
  • Thus, we conclude that TSA1 induction by Zap1p is an adaptive response to deal with the increased oxidative stress caused by zinc deficiency [3].
 

Anatomical context of ZNF569

  • Overexpression of ZNF569 in COS-7 cells inhibited the transcriptional activities of SRE and AP-1, which may be silenced by siRNA [6].
  • Expression of ZNF569 was found in most of the examined human adult and embryonic tissues with a higher level in heart and skeletal muscles [6].
  • ZAP-1 (zona pellucida gene activating protein-1) is a putative transcription factor controlling the oocyte-specific expression of mouse and human zona pellucida genes [5].
 

Associations of ZNF569 with chemical compounds

  • The methyl-for-picolyl substitutions in ZAP1 and ZAP2 have a negligible effect on the optical spectrum of the fluorophore but elevate the quantum yields (Phi = 0.82 (ZAP1), 0.74 (ZAP2)) to values near that of Zn(2+)-saturated ZP1 (Phi = 0.92) [7].
 

Analytical, diagnostic and therapeutic context of ZNF569

  • To identify genes important for growth in low zinc, DNA microarrays were used to identify genes directly regulated by Zap1p [3].

References

  1. Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts. Bird, A.J., Gordon, M., Eide, D.J., Winge, D.R. EMBO J. (2006) [Pubmed]
  2. Human heterochromatin proteins form large domains containing KRAB-ZNF genes. Vogel, M.J., Guelen, L., de Wit, E., Hupkes, D.P., Lod??n, M., Talhout, W., Feenstra, M., Abbas, B., Classen, A.K., van Steensel, B. Genome Res. (2006) [Pubmed]
  3. Regulation of the Yeast TSA1 Peroxiredoxin by ZAP1 Is an Adaptive Response to the Oxidative Stress of Zinc Deficiency. Wu, C.Y., Bird, A.J., Winge, D.R., Eide, D.J. J. Biol. Chem. (2007) [Pubmed]
  4. Zinc metalloregulation of the zinc finger pair domain. Bird, A.J., Swierczek, S., Qiao, W., Eide, D.J., Winge, D.R. J. Biol. Chem. (2006) [Pubmed]
  5. ZAP-1 DNA binding activity is first detected at the onset of zona pellucida gene expression in embryonic mouse oocytes. Millar, S.E., Lader, E.S., Dean, J. Dev. Biol. (1993) [Pubmed]
  6. ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. Huang, X., Yuan, W., Huang, W., Bai, Y., Deng, Y., Zhu, C., Liang, P., Li, Y., Du, X., Liu, M., Wang, Y., Wu, X. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  7. Analogues of zinpyr-1 provide insight into the mechanism of zinc sensing. Goldsmith, C.R., Lippard, S.J. Inorganic chemistry. (2006) [Pubmed]
 
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