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Gene Review:

CrmD - TNF receptor CrmD

Cowpox virus

Loparev, V.N. et al., Alcamí, A. et al.

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Disease relevance of CrmD

Possessing up to three TNFRs, including CrmD, which is secreted as disulfide-linked complexes in varied amounts by CPV and ECT, likely enhances the dynamics of the immune modulating mechanisms of orthopoxviruses [1].
CrmD was identified recently in CPV and ectromelia virus but the gene is absent in VV Copenhagen [2].
Cowpox virus (CPV) encodes three vTNFRs (CrmB, CrmC and CrmD) [2].

High impact information on CrmD

Bacterial maltose-binding proteins containing the CPV or ECT CrmD cysteine-rich region bound TNF and lymphotoxin-alpha (LTalpha) and blocked their in vitro cytolytic activity [1].
The protein, CrmD, contains a transport signal; a 151-aa cysteine-rich region with 21 cysteines that align with human TNFRII ligand-binding region cysteines; and C-terminal region sequences that are highly diverged from cellular TNFR C-terminal region sequences involved in signal transduction [1].

References

A third distinct tumor necrosis factor receptor of orthopoxviruses. Loparev, V.N., Parsons, J.M., Knight, J.C., Panus, J.F., Ray, C.A., Buller, R.M., Pickup, D.J., Esposito, J.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Vaccinia virus strains Lister, USSR and Evans express soluble and cell-surface tumour necrosis factor receptors. Alcamí, A., Khanna, A., Paul, N.L., Smith, G.L. J. Gen. Virol. (1999) [Pubmed]

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