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Gene Review:

SFV_s010L - Epidermal growth factor

Rabbit fibroma virus

Upton, C. et al., Sabourdy, F. et al., Ye, Y.K. et al.

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Disease relevance of SFV_s010L

The SFV/myxoma junction at this location maps 5' to a growth factor gene (SFGF) which is related to those encoding epidermal growth factor and transforming growth factor-alpha [1].
However, they are not exchangeable and MGF cannot substitute for SFGF in the genesis of fibromas [2].
However, both have a virally encoded homologue of the epidermal growth factor (namely SFGF and MGF, respectively) that is considered to be crucial for poxvirus tumorigenesis [2].
The synthetic SFGF accelerated precocious incisor eruption and eyelid opening in newborn mice and also retarded the overall growth rates of hair, body weight and body length when administered in dosages of 4 to 6 micrograms per gram of body weight [3].

High impact information on SFV_s010L

In summary, MRV has received the following ORFs from SFV: at the left terminus T5 (fusion), T6, T7, and T8; at the right terminus, T5 (fusion), T6, T7, T8, T9-R, SFGF, and T11-R (fusion) [1].

References

Tumorigenic poxviruses: fine analysis of the recombination junctions in malignant rabbit fibroma virus, a recombinant between Shope fibroma virus and myxoma virus. Upton, C., Macen, J.L., Maranchuk, R.A., DeLange, A.M., McFadden, G. Virology (1988) [Pubmed]
Tumorigenic poxviruses: growth factors in a viral context? Sabourdy, F., Casteignau, A., Gelfi, J., Deceroi, S., Delverdier, M., Messud-Petit, F.L. J. Gen. Virol. (2004) [Pubmed]
Shope fibroma virus growth factor exhibits epidermal growth factor activities in newborn mice. Ye, Y.K., Lin, Y.Z., Tam, J.P. Biochem. Biophys. Res. Commun. (1988) [Pubmed]

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