The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

US3  -  tegument protein; phosphorylates nuclear...

Human herpesvirus 2

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of US3

  • BACKGROUND: Although the US3 gene product of herpes simplex virus (HSV) has been identified as a serine/threonine protein kinase (PK), the functions are poorly understood [1].
  • RESULTS: We found that US3 PK of HSV-2 induced disruption of actin filaments, cell rounding and accumulation of binucleate cells in HEp2 cells [1].
  • These results indicate that a US3 deficiency alters the induction of the host immune response; therefore, the inactivation of US3 may be a promising strategy in the development of novel vaccines for genital herpes [2].
 

High impact information on US3

  • US3 protein kinase of herpes simplex virus type 2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice [3].
  • Viral clearance from the vaginal mucosa was more rapid in mice infected with a US3-deficient mutant L1BR1 as compared with a wild-type 186 or YY2 (US2-deficient mutant) infection, although there was no significant difference among them in initial growth in the early stage of infection [2].
  • Previously, we established HEp2 cell lines which express the US3 protein kinase of herpes simplex virus type 2 upon induction with IPTG [4].
  • Using these cells, we examined whether expression of US3 is sufficient to protect cells from apoptotic cell death induced by sorbitol [4].
  • Moreover, we found that infection of a keratinocyte-derived cell line, A431, with a US3-deficient virus, results in cytopathic effects that are morphologically distinct from those induced by wild-type and revertant viruses, suggesting that US3 PK may be important for interaction between HSV-2 and peripheral epithelial cells [5].
 

Chemical compound and disease context of US3

 

Biological context of US3

 

Anatomical context of US3

 

Analytical, diagnostic and therapeutic context of US3

References

  1. Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation. Murata, T., Goshima, F., Daikoku, T., Takakuwa, H., Nishiyama, Y. Genes Cells (2000) [Pubmed]
  2. Effect of the deletion of US2 and US3 from herpes simplex virus type 2 on immune responses in the murine vagina following intravaginal infection. Inagaki-Ohara, K., Iwasaki, T., Watanabe, D., Kurata, T., Nishiyama, Y. Vaccine (2001) [Pubmed]
  3. US3 protein kinase of herpes simplex virus type 2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice. Asano, S., Honda, T., Goshima, F., Watanabe, D., Miyake, Y., Sugiura, Y., Nishiyama, Y. J. Gen. Virol. (1999) [Pubmed]
  4. Herpes simplex virus type 2 US3 blocks apoptosis induced by sorbitol treatment. Murata, T., Goshima, F., Yamauchi, Y., Koshizuka, T., Takakuwa, H., Nishiyama, Y. Microbes Infect. (2002) [Pubmed]
  5. Phosphorylation of cytokeratin 17 by herpes simplex virus type 2 US3 protein kinase. Murata, T., Goshima, F., Nishizawa, Y., Daikoku, T., Takakuwa, H., Ohtsuka, K., Yoshikawa, T., Nishiyama, Y. Microbiol. Immunol. (2002) [Pubmed]
  6. The pathogenicity of a US3 protein kinase-deficient mutant of herpes simplex virus type 2 in mice. Kurachi, R., Daikoku, T., Tsurumi, T., Maeno, K., Nishiyama, Y., Kurata, T. Arch. Virol. (1993) [Pubmed]
 
WikiGenes - Universities